EXCEPTIONAL RESPONSE OF REFRACTORY ATLL WITH MDM4 AMPLIFICATION TO NOVEL STAPLED PEPTIDE DUAL MDM4/2 INHIBITOR
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DOI: 10.1002/hon.210_2631
Abstract: to quantify sources of variability, including body size effects, on ADC and monomethyl auristatin E (MMAE) PK in paediatric pts with classical Hodgkin lymphoma (cHL). Methods: POPPK base-models were based on previously reported models. A… read more here.
Keywords: mdm4; model; auc; based dosing ... See more keywords
Downregulation of microRNA‐23b protects against ischemia‐reperfusion injury via p53 signaling pathway by upregulating MDM4 in rats
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DOI: 10.1002/jcb.27748
Abstract: Total knee arthroplasty is a commonly performed safe procedure and typically executed in severe knee arthritis, but it also triggers ischemia‐reperfusion injury (IRI). More recently, microRNAs (miRs) have been reported to play a contributory role… read more here.
Keywords: p53 signaling; mdm4; mir 23b; signaling pathway ... See more keywords
Mdm4 supports DNA replication in a p53-independent fashion
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DOI: 10.1038/s41388-020-1325-1
Abstract: The Mdm4 (alias MdmX) oncoprotein, like its paralogue and interaction partner Mdm2, antagonizes the tumor suppressor p53. p53-independent roles of the Mdm proteins are emerging, and we have reported the ability of Mdm2 to modify… read more here.
Keywords: mdm4; dna replication; replication; p53 independent ... See more keywords
MicroRNA miR-34a-5p inhibition restrains oxidative stress injury of macrophages by targeting MDM4
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DOI: 10.1177/17085381211069447
Abstract: Objective Atherosclerosis is a chronic cardiovascular disease associated with oxidative stress damage, which is caused by excessive oxidation of low-density lipoprotein (ox-LDL). The role of microRNA miR-34a-5p on oxidative stress in ox-LDL–treated macrophages was investigated… read more here.
Keywords: mdm4; stress injury; oxidative stress; microrna mir ... See more keywords
MDM4 as a Prognostic Factor for Patients With Gastric Cancer With Low Expression of p53
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DOI: 10.21873/anticanres.14906
Abstract: Background/Aim: The oncoproteins murine double minute (MDM) 2 and MDM4 inactivate tumor-suppressor protein p53. Their mutual relationship with the prognosis of gastric cancer (GC) remains unknown. Patients and Methods: Expression of MDM2, MDM4, and p53… read more here.
Keywords: expression p53; mdm4; expression; p53 ... See more keywords
Small molecule MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status
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DOI: 10.3389/fonc.2022.933446
Abstract: MDM2 and MDM4 proteins are key negative regulators of tumor suppressor p53. MDM2 and MDM4 interact via their RING domains and form a heterodimer polyubiquitin E3 ligase essential for p53 degradation. MDM4 also forms heterodimer… read more here.
Keywords: mdm4; apoptosis; mdm2 mdm4; p53 ... See more keywords
Estrogens Counteract Platinum-Chemosensitivity by Modifying the Subcellular Localization of MDM4
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DOI: 10.3390/cancers11091349
Abstract: Estrogen activity towards cancer-related pathways can impact therapeutic intervention. Recent omics data suggest possible crosstalk between estrogens/gender and MDM4, a key regulator of p53. Since MDM4 can either promote cell transformation or enhance DNA damage-sensitivity,… read more here.
Keywords: mdm4; estrogen; estrogens counteract; sensitivity ... See more keywords