MDMA alone affects sensorimotor and prepulse inhibition responses in mice and rats: tips in the debate on potential MDMA unsafety in human activity
Sign Up to like & getrecommendations! Published in 2018 at "Forensic Toxicology"
DOI: 10.1007/s11419-018-0444-7
Abstract: PurposeMDMA is a psychoactive drug that has been increasingly abused worldwide, due to its entactogenic properties. However, concerns on its safety exist, particularly regarding its effects on attentional skills and performance. Evidence from the literature… read more here.
Keywords: inhibition responses; inhibition; sensorimotor prepulse; prepulse inhibition ... See more keywords
Binge ethanol and MDMA combination exacerbates HSP27 and Trx‐1 (biomarkers of toxic cardiac effects) expression in right ventricle
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.01.050
Abstract: Aims: Oxidative stress caused by exposure to drugs of abuse such as ethanol or 3, 4 methylenedioxymethamphetamine (MDMA) may derive from direct or indirect effects in many organs including the heart. The aim of the… read more here.
Keywords: ethanol mdma; mdma; binge ethanol; trx ... See more keywords
Developmental neurotoxicity of MDMA. A systematic literature review summarized in a putative adverse outcome pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2019.12.007
Abstract: The increasing use of illegal drugs by pregnant women causes a public health concern because it is associated with health risks for mothers and their developing children. One of such drugs is MDMA (3,4-methylenedioxymethamphetamine) or… read more here.
Keywords: adverse outcome; outcome pathway; mdma; developmental neurotoxicity ... See more keywords
Effects of para-methoxyamphetamine (PMA) on agonistic encounters between male mice
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2018.02.002
Abstract: ABSTRACT Para‐methoxyamphetamine (PMA) is a synthetic drug chemically similar to the recreational drug 3,4‐methylenedioxy‐methamphetamine (MDMA or “ecstasy”) and often replaces MDMA in tablets that show an “ecstasy” logo. PMA displays a higher toxic potential than… read more here.
Keywords: pma; methoxyamphetamine pma; male mice; mdma ... See more keywords
Autophagy inhibition plays a protective role against 3, 4‐methylenedioxymethamphetamine (MDMA)‐induced loss of serotonin transporters and depressive‐like behaviors in rats
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2019.02.026
Abstract: Graphical abstract Figure. No Caption available. Abstract The 3,4‐methylenedioxymethamphetamine (MDMA) is a popular recreational drug, which ultimately leads to serotonergic (5‐HT) neurotoxicity and psychiatric disorders. Previous in vitro studies have consistently demonstrated that MDMA provokes… read more here.
Keywords: autophagy inhibition; mdma induced; mdma; methylenedioxymethamphetamine mdma ... See more keywords
Monitoring MDMA metabolites in urban wastewater as novel biomarkers of consumption.
Sign Up to like & getrecommendations! Published in 2017 at "Water research"
DOI: 10.1016/j.watres.2017.01.063
Abstract: Consumption of 3,4-methylendioxymethamphetamine (MDMA) has been always estimated by measuring the parent substance through chemical analysis of wastewater. However, this may result in an overestimation of the use if the substance is directly disposed in… read more here.
Keywords: use; mdma metabolites; biomarkers consumption; mdma ... See more keywords
Better living through chemistry: MDMA’s prosocial mechanism as a starting point for improved therapeutics
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-00803-8
Abstract: MDMA, the once-demonized party drug still known as “ecstasy”, is racing toward FDA approval as a potentially powerful adjunct to psychotherapy for the treatment of PTSD. However, MDMA has abuse potential, and long term use… read more here.
Keywords: mechanism; chemistry; effect; mdma ... See more keywords
How Postmortem Redistribution of MDMA in Acute Alcohol-MDMA Combined-Use Rats Change under Effects of Alcohol
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DOI: 10.1038/s41598-017-04416-y
Abstract: MDMA is often taken recreationally with alcohol as combined-use. The objective was to determine MDMA postmortem redistribution (PMR) and corresponding effects in combined-style under different storage conditions. Steps were 20%-mixture of alcohol-water for initial 4… read more here.
Keywords: postmortem redistribution; use rats; mdma; alcohol ... See more keywords
The influence of the host microbiome on 3,4-methylenedioxymethamphetamine (MDMA)-induced hyperthermia and vice versa
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DOI: 10.1038/s41598-019-40803-3
Abstract: Hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) can be life-threatening. Here, we investigate the role of the gut microbiome and TGR5 bile acid receptors in MDMA-mediated hyperthermia. Fourteen days prior to treatment with MDMA, male Sprague-Dawley rats… read more here.
Keywords: mdma induced; induced hyperthermia; influence host; mdma ... See more keywords
Motivations for Using MDMA (Ecstasy/Molly) among African Americans: Implications for Prevention and Harm-Reduction Programs
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Psychoactive Drugs"
DOI: 10.1080/02791072.2017.1305518
Abstract: ABSTRACT Despite the growing popularity of MDMA (ecstasy/molly) among African Americans, their motives for using the drug are still largely unknown. The purpose of this study was to identify and describe the most salient motivations… read more here.
Keywords: among african; using mdma; mdma ecstasy; african americans ... See more keywords
3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) use and transitions to injection drug use among street-involved youth
Sign Up to like & getrecommendations! Published in 2018 at "Substance Abuse"
DOI: 10.1080/08897077.2018.1528493
Abstract: Abstract Background: Despite the popularity of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) among young people across North America and Europe, MDMA is rarely explored in studies of young people at high risk of injecting drugs. We conducted a… read more here.
Keywords: use; involved youth; mdma; street involved ... See more keywords