Issues in Clinical Trial Design-Lessons From the FDA's Rejection of MDMA.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2025.0442
Abstract: This Viewpoint explores potential justifications underlying the US Food and Drug Administration (FDA)’s rejection of methylenedioxymethamphetamine (MDMA) as a treatment for posttraumatic stress disorder, including lack of blinding and issues around the integrity of relevant… read more here.
Keywords: mdma; clinical trial; rejection; fda rejection ... See more keywords
MDMA alone affects sensorimotor and prepulse inhibition responses in mice and rats: tips in the debate on potential MDMA unsafety in human activity
Sign Up to like & getrecommendations! Published in 2018 at "Forensic Toxicology"
DOI: 10.1007/s11419-018-0444-7
Abstract: PurposeMDMA is a psychoactive drug that has been increasingly abused worldwide, due to its entactogenic properties. However, concerns on its safety exist, particularly regarding its effects on attentional skills and performance. Evidence from the literature… read more here.
Keywords: inhibition responses; inhibition; sensorimotor prepulse; prepulse inhibition ... See more keywords
Binge ethanol and MDMA combination exacerbates HSP27 and Trx‐1 (biomarkers of toxic cardiac effects) expression in right ventricle
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.01.050
Abstract: Aims: Oxidative stress caused by exposure to drugs of abuse such as ethanol or 3, 4 methylenedioxymethamphetamine (MDMA) may derive from direct or indirect effects in many organs including the heart. The aim of the… read more here.
Keywords: ethanol mdma; mdma; binge ethanol; trx ... See more keywords
Developmental neurotoxicity of MDMA. A systematic literature review summarized in a putative adverse outcome pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2019.12.007
Abstract: The increasing use of illegal drugs by pregnant women causes a public health concern because it is associated with health risks for mothers and their developing children. One of such drugs is MDMA (3,4-methylenedioxymethamphetamine) or… read more here.
Keywords: adverse outcome; outcome pathway; mdma; developmental neurotoxicity ... See more keywords
Effects of para-methoxyamphetamine (PMA) on agonistic encounters between male mice
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2018.02.002
Abstract: ABSTRACT Para‐methoxyamphetamine (PMA) is a synthetic drug chemically similar to the recreational drug 3,4‐methylenedioxy‐methamphetamine (MDMA or “ecstasy”) and often replaces MDMA in tablets that show an “ecstasy” logo. PMA displays a higher toxic potential than… read more here.
Keywords: pma; methoxyamphetamine pma; male mice; mdma ... See more keywords
Autophagy inhibition plays a protective role against 3, 4‐methylenedioxymethamphetamine (MDMA)‐induced loss of serotonin transporters and depressive‐like behaviors in rats
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2019.02.026
Abstract: Graphical abstract Figure. No Caption available. Abstract The 3,4‐methylenedioxymethamphetamine (MDMA) is a popular recreational drug, which ultimately leads to serotonergic (5‐HT) neurotoxicity and psychiatric disorders. Previous in vitro studies have consistently demonstrated that MDMA provokes… read more here.
Keywords: autophagy inhibition; mdma induced; mdma; methylenedioxymethamphetamine mdma ... See more keywords
Monitoring MDMA metabolites in urban wastewater as novel biomarkers of consumption.
Sign Up to like & getrecommendations! Published in 2017 at "Water research"
DOI: 10.1016/j.watres.2017.01.063
Abstract: Consumption of 3,4-methylendioxymethamphetamine (MDMA) has been always estimated by measuring the parent substance through chemical analysis of wastewater. However, this may result in an overestimation of the use if the substance is directly disposed in… read more here.
Keywords: use; mdma metabolites; biomarkers consumption; mdma ... See more keywords
MDMA-assisted therapy: challenges, clinical trials, and the future of MDMA in treating behavioral disorders
Sign Up to like & getrecommendations! Published in 2025 at "CNS Spectrums"
DOI: 10.1017/s1092852925000057
Abstract: Abstract This chapter explores the complex and controversial path of MDMA-assisted therapy (MDMA-AT) for treating post-traumatic stress disorder (PTSD) and other behavioral disorders. It covers MDMA’s history from research to recreation to medicine, the pivotal… read more here.
Keywords: mdma; behavioral disorders; assisted therapy; mdma treating ... See more keywords
Better living through chemistry: MDMA’s prosocial mechanism as a starting point for improved therapeutics
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-00803-8
Abstract: MDMA, the once-demonized party drug still known as “ecstasy”, is racing toward FDA approval as a potentially powerful adjunct to psychotherapy for the treatment of PTSD. However, MDMA has abuse potential, and long term use… read more here.
Keywords: mechanism; chemistry; effect; mdma ... See more keywords
Acute effects of R-MDMA, S-MDMA, and racemic MDMA in a randomized double-blind cross-over trial in healthy participants
Sign Up to like & getrecommendations! Published in 2024 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-024-01972-6
Abstract: Racemic 3,4-methylenedioxymethamphetamine (MDMA) acutely increases mood, feelings of empathy, trust, and closeness to others and is investigated to assist psychotherapy. Preclinical research indicates that S-MDMA releases monoamines and oxytocin more potently than R-MDMA, whereas R-MDMA… read more here.
Keywords: mdma; mdma 125; mdma administration; effects mdma ... See more keywords
How Postmortem Redistribution of MDMA in Acute Alcohol-MDMA Combined-Use Rats Change under Effects of Alcohol
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04416-y
Abstract: MDMA is often taken recreationally with alcohol as combined-use. The objective was to determine MDMA postmortem redistribution (PMR) and corresponding effects in combined-style under different storage conditions. Steps were 20%-mixture of alcohol-water for initial 4… read more here.
Keywords: postmortem redistribution; use rats; mdma; alcohol ... See more keywords