Calculation of hot spots for protein–protein interaction in p53/PMI‐MDM2/MDMX complexes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.25592
Abstract: The recently developed MM/GBSA_IE method is applied to computing hot and warm spots in p53/PMI‐MDM2/MDMX protein–protein interaction systems. Comparison of the calculated hot (>2 kcal/mol) and warm spots (>1 kcal/mol) in P53 and PMI proteins… read more here.
Keywords: mdm2 mdmx; p53 pmi; mdmx;
A small-molecule inhibitor of MDMX suppresses cervical cancer cells via the inhibition of E6-E6AP-p53 axis.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacological research"
DOI: 10.1016/j.phrs.2022.106128
Abstract: Dysfunction of p53 is observed in many malignant tumors, which is related to cancer susceptibility. In cervical cancer, p53 is primarily degradated through the complex of high-risk human papillomaviruses (HPV) oncoprotein E6 and E6-associated protein… read more here.
Keywords: cancer; cervical cancer; small molecule; p53 ... See more keywords
Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aao3003
Abstract: Dual inhibition of MDMX and MDM2 by an α-helical p53-stapled peptide (ALRN-6924) results in robust antitumor activity in acute myeloid leukemia. A new staple of leukemia treatment? As suggested by their name, tumor suppressor genes… read more here.
Keywords: mdmx mdm2; inhibition; mdmx; alrn 6924 ... See more keywords
Abstract 2525: Analyzing the role of MDMX for regulating cell death in prostate cancer cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2525
Abstract: Prostate cancer (PCa) is the most prominent cancer type and the second leading cause of cancer death among men in the USA. The five-year survival rate for localized PCa is 98% but drops to 31%… read more here.
Keywords: cell death; cell; cancer; prostate cancer ... See more keywords
Abstract 3929: MDMX overexpression in cancer cells confers significant resistance to MDMX inhibitor XI-006 and may modulate chemosensitivity through suppressing p53 activation of pro-apoptotic factors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3929
Abstract: MDM2 inhibition has gained popularity in recent years as a therapeutic strategy in targeting both solid tumors and hematological malignancies, and several small molecule inhibitors of the p53-MDM2 binding interface have progressed into clinical trials… read more here.
Keywords: inhibitor 006; mdmx inhibitor; overexpression; mdmx ... See more keywords
The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2)
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22320
Abstract: Mouse double minute 2 (Mdm2) and MdmX dimerize in response to low levels of genotoxic stress to function in a ubiquitinating complex, which signals for destabilization of p53. Under growth conditions, Mdm2 functions as a… read more here.
Keywords: murine double; mdm2; double minute; mdmx ... See more keywords
Contemplations on MDMX (MDM4) driving triple negative breast cancer circulating tumor cells and metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Oncotarget"
DOI: 10.18632/oncotarget.27134
Abstract: MDMX (MDM4) is emerging as an important breast cancer (BC) biomarker, and oncoprotein, that can be targeted in combination with its well-known family member MDM2. While MDM2 has previously been implicated in driving BC metastasis,… read more here.
Keywords: metastasis; mtp53; mdmx; breast cancer ... See more keywords
Bionic Power Play: Dual-Targeting MDMX/MDM2 to Reboot p53 to Beat Lung Adenocarcinoma’s Immune Tricks
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s533208
Abstract: Background and Aim MDM2 and MDMX are key regulators of the tumor suppressor p53 and are implicated in immune escape mechanisms in lung adenocarcinoma. Overexpression of these proteins inhibits p53 activity, limiting the immune system’s… read more here.
Keywords: mdmx; lung; mdm2; lung adenocarcinoma ... See more keywords
Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.01389
Abstract: The oncogene MDMX, also known as MDM4 is a critical negative regulator of the tumor suppressor p53 and has been implicated in the initiation and progression of human cancers. Increasing evidence indicates that MDMX is… read more here.
Keywords: targeting mdmx; mdmx; cancer; p53 ... See more keywords
MDMX Regulates Transcriptional Activity of p53 and FOXO Proteins to Stimulate Proliferation of Melanoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14184482
Abstract: Simple Summary We have investigated the transcriptional changes occurring in uveal and cutaneous melanoma cell lines upon depletion of MDMX (aka:MDM4). Computational analyses of the mRNAs/genes affected upon MDMX depletion determined that many were containing… read more here.
Keywords: cell; melanoma; activity; p53 ... See more keywords