Calculation of hot spots for protein–protein interaction in p53/PMI‐MDM2/MDMX complexes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.25592
Abstract: The recently developed MM/GBSA_IE method is applied to computing hot and warm spots in p53/PMI‐MDM2/MDMX protein–protein interaction systems. Comparison of the calculated hot (>2 kcal/mol) and warm spots (>1 kcal/mol) in P53 and PMI proteins… read more here.
Keywords: mdm2 mdmx; p53 pmi; mdmx;
A small-molecule inhibitor of MDMX suppresses cervical cancer cells via the inhibition of E6-E6AP-p53 axis.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacological research"
DOI: 10.1016/j.phrs.2022.106128
Abstract: Dysfunction of p53 is observed in many malignant tumors, which is related to cancer susceptibility. In cervical cancer, p53 is primarily degradated through the complex of high-risk human papillomaviruses (HPV) oncoprotein E6 and E6-associated protein… read more here.
Keywords: cancer; cervical cancer; small molecule; p53 ... See more keywords
Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aao3003
Abstract: Dual inhibition of MDMX and MDM2 by an α-helical p53-stapled peptide (ALRN-6924) results in robust antitumor activity in acute myeloid leukemia. A new staple of leukemia treatment? As suggested by their name, tumor suppressor genes… read more here.
Keywords: mdmx mdm2; inhibition; mdmx; alrn 6924 ... See more keywords
Abstract 2525: Analyzing the role of MDMX for regulating cell death in prostate cancer cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2525
Abstract: Prostate cancer (PCa) is the most prominent cancer type and the second leading cause of cancer death among men in the USA. The five-year survival rate for localized PCa is 98% but drops to 31%… read more here.
Keywords: cell death; cell; cancer; prostate cancer ... See more keywords
Abstract 3929: MDMX overexpression in cancer cells confers significant resistance to MDMX inhibitor XI-006 and may modulate chemosensitivity through suppressing p53 activation of pro-apoptotic factors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3929
Abstract: MDM2 inhibition has gained popularity in recent years as a therapeutic strategy in targeting both solid tumors and hematological malignancies, and several small molecule inhibitors of the p53-MDM2 binding interface have progressed into clinical trials… read more here.
Keywords: inhibitor 006; mdmx inhibitor; overexpression; mdmx ... See more keywords
The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2)
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22320
Abstract: Mouse double minute 2 (Mdm2) and MdmX dimerize in response to low levels of genotoxic stress to function in a ubiquitinating complex, which signals for destabilization of p53. Under growth conditions, Mdm2 functions as a… read more here.
Keywords: murine double; mdm2; double minute; mdmx ... See more keywords
Contemplations on MDMX (MDM4) driving triple negative breast cancer circulating tumor cells and metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Oncotarget"
DOI: 10.18632/oncotarget.27134
Abstract: MDMX (MDM4) is emerging as an important breast cancer (BC) biomarker, and oncoprotein, that can be targeted in combination with its well-known family member MDM2. While MDM2 has previously been implicated in driving BC metastasis,… read more here.
Keywords: metastasis; mtp53; mdmx; breast cancer ... See more keywords
Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.01389
Abstract: The oncogene MDMX, also known as MDM4 is a critical negative regulator of the tumor suppressor p53 and has been implicated in the initiation and progression of human cancers. Increasing evidence indicates that MDMX is… read more here.
Keywords: targeting mdmx; mdmx; cancer; p53 ... See more keywords
MDMX Regulates Transcriptional Activity of p53 and FOXO Proteins to Stimulate Proliferation of Melanoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14184482
Abstract: Simple Summary We have investigated the transcriptional changes occurring in uveal and cutaneous melanoma cell lines upon depletion of MDMX (aka:MDM4). Computational analyses of the mRNAs/genes affected upon MDMX depletion determined that many were containing… read more here.
Keywords: cell; melanoma; activity; p53 ... See more keywords