Abstract 3929: MDMX overexpression in cancer cells confers significant resistance to MDMX inhibitor XI-006 and may modulate chemosensitivity through suppressing p53 activation of pro-apoptotic factors
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DOI: 10.1158/1538-7445.am2023-3929
Abstract: MDM2 inhibition has gained popularity in recent years as a therapeutic strategy in targeting both solid tumors and hematological malignancies, and several small molecule inhibitors of the p53-MDM2 binding interface have progressed into clinical trials… read more here.
Keywords: inhibitor 006; mdmx inhibitor; overexpression; mdmx ... See more keywords