Studying Homo-oligomerization and Hetero-oligomerization of MDMX and MDM2 Proteins in Single Living Cells by Using In Situ Fluorescence Correlation Spectroscopy.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.1c00153
Abstract: Protein oligomerization plays a very important role in many physiological processes. p53 acts as a key tumor suppressor by regulating cell cycle arrest, DNA repair, and apoptosis, and its antitumor activity is regulated by the… read more here.
Keywords: mdmx mdm2; hetero; spectroscopy; oligomerization ... See more keywords
Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia
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DOI: 10.1126/scitranslmed.aao3003
Abstract: Dual inhibition of MDMX and MDM2 by an α-helical p53-stapled peptide (ALRN-6924) results in robust antitumor activity in acute myeloid leukemia. A new staple of leukemia treatment? As suggested by their name, tumor suppressor genes… read more here.
Keywords: mdmx mdm2; inhibition; mdmx; alrn 6924 ... See more keywords
Abstract 5682: Micro RNA level changes in prostate cancer cells treated with MDMX and MDM2 inhibitors
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-5682
Abstract: INTRODUCTION: Prostate Cancer (PCa) is the most common non-cutaneous cancer and the second leading cause of cancer death among men in the United States. Most of the PCa cases are diagnosed in men between the… read more here.
Keywords: cancer; mdm2; cells treated; mdmx mdm2 ... See more keywords