Neuropharmacology of 3,4-Methylenedioxypyrovalerone (MDPV), Its Metabolites, and Related Analogs.
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DOI: 10.1007/7854_2016_53
Abstract: 3,4-Methylenedioxypyrovalerone (MDPV) is a psychoactive component of so-called bath salts products that has caused serious medical consequences in humans. In this chapter, we review the neuropharmacology of MDPV and related analogs, and supplement the discussion… read more here.
Keywords: neuropharmacology methylenedioxypyrovalerone; mdpv metabolites; mdpv; related analogs ... See more keywords
Role of hypocretin/orexin receptor blockade on drug-taking and ultrasonic vocalizations (USVs) associated with low-effort self-administration of cathinone-derived 3,4-methylenedioxypyrovalerone (MDPV) in rats
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DOI: 10.1007/s00213-017-4709-3
Abstract: RationaleSynthetic psychostimulant abuse, including cathinone-derived 3,4-methylenedioxypyrovalerone (MDPV), continues to increase in many countries. Similar to cocaine but with greater potency, MDPV elicits a transient sympathomimetic response by blocking cellular uptake of dopamine (DA) and norepinephrine… read more here.
Keywords: self administration; drug; mdpv; drug taking ... See more keywords
Active vaccination reduces reinforcing effects of MDPV in male Sprague-Dawley rats trained to self-administer cocaine
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DOI: 10.1007/s00213-020-05558-0
Abstract: 3,4-Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone abused for its cocaine-like psychostimulant effects in “bath salts” products. While there are currently no pharmacotherapies for MDPV abuse, rodent studies suggest immunotherapy may offer a feasible treatment option.… read more here.
Keywords: self administration; mdpv; active vaccination; cocaine ... See more keywords
MDPV self-administration in female rats: influence of reinforcement history.
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DOI: 10.1007/s00213-020-05726-2
Abstract: RATIONALE A subset of male rats that self-administer 3,4-methylenedioxypyrovalerone (MDPV) have unusually high levels of drug intake; however, factor(s) that influence this behavior (e.g., reinforcement history and sex) are unknown. OBJECTIVES Characterize the reinforcing potency… read more here.
Keywords: self administration; mdpv self; mdpv; history ... See more keywords
MDPV-induced aggression in humans not established
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DOI: 10.1007/s00414-019-02165-3
Abstract: To the Editors: We read with interest the article by De-Giogio et al. [1] investigating the acute and repeated administration of 3,4methylenedioxypyrovalerone (MDPV) on aggressive responding in mice. This is an important issue because MDPV… read more here.
Keywords: synthetic cathinones; ecologically relevant; induced aggression; aggression ... See more keywords
Reply to “MDPV-induced aggression in humans not established”
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Legal Medicine"
DOI: 10.1007/s00414-019-02176-0
Abstract: We appreciate the comments made by KY O’Malley and C Medina-Kirchner, and in this response, we take the opportunity to clarify some of the issues raised. First, the authors defined the conclusion of our study… read more here.
Keywords: reply mdpv; study; study published; mdpv ... See more keywords
Organ distribution of 4-MEC, MDPV, methoxetamine and α-PVP: comparison of QuEChERS and SPE
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DOI: 10.1007/s11419-018-0408-y
Abstract: PurposeAn organ distribution investigation was carried out on two deceased (A and B) who consumed 4-methylethcathinone (4-MEC), methylenedioxypyrovalerone (MDPV), methoxetamine (MXE) and α-pyrrolidinopentiophenone (α-PVP).MethodsThe detection of the aforementioned drugs in the specimens was performed on… read more here.
Keywords: mdpv methoxetamine; mec mdpv; mdpv; organ distribution ... See more keywords
Toxicological investigation of forensic cases related to the designer drug 3,4-methylenedioxypyrovalerone (MDPV): Detection, quantification and studies on human metabolism by GC-MS.
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DOI: 10.1016/j.forsciint.2017.01.021
Abstract: 3,4-methylenedioxypyrovalerone (MDPV) is a synthetic cathinone belonging to the class of α-pyrrolidinophenones that become increasingly popular as a designer psychostimulant. Here, we report a comprehensive collection of MDPV exposure with quantitative serum level confirmation in… read more here.
Keywords: mdpv demethylenyl; mdpv; methylenedioxypyrovalerone mdpv; oxo mdpv ... See more keywords
Neuroadaptive changes and behavioral effects after a sensitization regime of MDPV
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DOI: 10.1016/j.neuropharm.2018.10.005
Abstract: &NA; 3,4‐methylenedioxypyrovalerone (MDPV) is a synthetic cathinone with cocaine‐like properties. In a previous work, we exposed adolescent mice to MDPV, finding sensitization to cocaine effects, and a higher vulnerability to cocaine abuse in adulthood. Here… read more here.
Keywords: neuroadaptive changes; treatment; mdpv; cocaine ... See more keywords
Non-conserved residues dictate dopamine transporter selectivity for the potent synthetic cathinone and psychostimulant MDPV
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DOI: 10.1016/j.neuropharm.2021.108820
Abstract: Clandestine chemists are currently exploiting the pyrrolidinophenone scaffold to develop new designer drugs that carry the risk of abuse and overdose. These drugs promote addiction through the rewarding effects of increased dopaminergic neurotransmission. 3,4-Methylenedioxypyrovalerone (MDPV)… read more here.
Keywords: non conserved; mdpv; dopamine transporter; conserved residues ... See more keywords
Dopamine D1-Like Receptor Agonist and D2-Like Receptor Antagonist (-)-Stepholidine Reduces Reinstatement of Drug-Seeking Behavior for 3,4-Methylenedioxypyrovalerone (MDPV) in Rats.
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DOI: 10.1021/acschemneuro.7b00510
Abstract: Psychostimulant reinforcement is mediated by stimulation of both dopamine (DA) D1-like and D2-like receptors, suggesting that pharmacotherapy agents with a dual DA receptor mechanism may be useful for managing psychostimulant abuse. (-)-Stepholidine (L-SPD) is a… read more here.
Keywords: seeking behavior; receptor agonist; like receptor; mdpv ... See more keywords