Bounding the Moment Deficit Rate on Crustal Faults using Geodetic Data: Methods†
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DOI: 10.1002/2017jb014300
Abstract: The geodetically-derived interseismic Moment Deficit Rate (MDR) provides a first-order constraint on earthquake potential, and can play an important role in seismic hazard assessment, but quantifying uncertainty in MDR is a challenging problem that has… read more here.
Keywords: moment; mdr; moment deficit; rate ... See more keywords
miRNA‐765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells
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DOI: 10.1002/2211-5463.12838
Abstract: Elucidation of the mechanisms underlying multidrug resistance (MDR) is required to ensure the efficacy of chemotherapy against gastric cancer (GC). To investigate this issue, here we identified that microRNA‐765 (miRNA‐765) is up‐regulated both in MDR… read more here.
Keywords: gastric cancer; mirna 765; mdr; multidrug resistance ... See more keywords
How Structure–Function Relationships of 1,4‐Naphthoquinones Combat Antimicrobial Resistance in Multidrug‐Resistant (MDR) Pathogens
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DOI: 10.1002/cmdc.202200471
Abstract: Antimicrobial resistance (AMR) is one of the top ten health‐related threats worldwide. Among several antimicrobial agents, naphthoquinones (NQs) of plant/chemical origin possess enormous structural and functional diversity and are effective against multidrug‐resistant (MDR) pathogens. 1,4‐NQs… read more here.
Keywords: structure; mdr; mdr pathogens; multidrug resistant ... See more keywords
Combination of dihydromyricetin and ondansetron strengthens antiproliferative efficiency of adriamycin in K562/ADR through downregulation of SORCIN: A new strategy of inhibiting P‐glycoprotein
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27141
Abstract: Though the advancement of chemotherapy drugs alleviates the progress of cancer, long‐term therapy with anticancer agents gradually leads to acquired multidrug resistance (MDR), which limits the survival outcomes in patients. It was shown that dihydromyricetin… read more here.
Keywords: antiproliferative efficiency; mdr; k562 adr; dmy ... See more keywords
d-Gluconic acid–based methotrexate prodrug–loaded mixed micelles composed of MDR reversing copolymer: in vitro and in vivo results
Sign Up to like & getrecommendations! Published in 2018 at "Colloid and Polymer Science"
DOI: 10.1007/s00396-018-4416-6
Abstract: AbstractThe main aim of the present research was to synthesize carbohydrate (d-gluconic acid, DGA) prodrug of methotrexate (MTX) to improve the aqueous solubility and to develop mixed micelles (MMs) composed of d-α-tocopheryl poly (ethylene glycol)… read more here.
Keywords: mdr; mdgac; mdr reversing; mixed micelles ... See more keywords
Emergence and spread in Taiwan of multidrug-resistant serotypes of nontyphoidal Salmonella
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DOI: 10.1007/s15010-021-01736-0
Abstract: Purpose Antimicrobial resistance of nontyphoidal Salmonella (NTS) is a threat to public health worldwide. Methods A study on longitudinally collected NTS isolates from a medical center in Taiwan from 2011 to 2019 was undertaken. The… read more here.
Keywords: xdr nts; mdr; nontyphoidal salmonella; multidrug ... See more keywords
Enhanced anticancer effect of doxorubicin by TPGS-coated liposomes with Bcl-2 siRNA-corona for dual suppression of drug resistance
Sign Up to like & getrecommendations! Published in 2020 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2019.10.003
Abstract: Multiple drug resistance (MDR) is a tough problem in developing hepatocellular carcinoma (HCC) therapy. Here, we developed TPGS-coated cationic liposomes with Bcl-2 siRNA corona to load doxorubicin (Dox) i.e., Bcl-2 siRNA/Dox-TPGS-LPs, to enhance anticancer effect… read more here.
Keywords: sirna corona; mdr; corona; bcl sirna ... See more keywords
Triggered ferroptotic polymer micelles for reversing multidrug resistance to chemotherapy.
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DOI: 10.1016/j.biomaterials.2019.119486
Abstract: Drug-tolerant persister cancer cells (PCCs) play an important role in the development of multidrug resistance (MDR) to anti-cancer drugs. This is due to the strong link between PCCs formation and epithelial-mesenchymal transition (EMT), as well… read more here.
Keywords: triggered ferroptotic; mdr; polymer micelles; ferroptotic polymer ... See more keywords
Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.10.020
Abstract: Phosphoinositide 3-kinase gamma isoform (PI3Kγ) plays a critical role in myeloid-derived cells of the immunosuppressive tumor microenvironment. IPI-549, a recently discovered small molecule selective PI3Kγ inhibitor, is currently under immuno-oncology clinical trials in combination with… read more here.
Keywords: immuno oncology; mdr; sw620 ad300; ipi 549 ... See more keywords
Novel niclosamide-derived adjuvants elevating the efficacy of polymyxin B against MDR Pseudomonas aeruginosa DK2.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114318
Abstract: Pseudomonas aeruginosa (P. aeruginosa) DK2 is a multidrug-resistant (MDR) gram-negative bacterial pathogen, being observed serious resistance to the 'last-resort' antibiotic, polymyxin B (PB). Combination therapies with adjuvants have emerged as effective strategies to reactivate the… read more here.
Keywords: aeruginosa dk2; pseudomonas aeruginosa; derived adjuvants; mdr ... See more keywords
Derivative of 5-cyano-6-phenylpyrimidin antagonizes ABCB1- and ABCG2-mediated multidrug resistance.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172611
Abstract: Multidrug resistance (MDR) leads to inadequate response to chemotherapy and cause failure in cancer treatment. One of the targeted approaches to overcome MDR in cancer cells is interfering or inhibiting ATP binding cassette (ABC) transporters.… read more here.
Keywords: transporter subfamily; mdr; abc transporter; cyano phenylpyrimidin ... See more keywords