Loperamide potentiates doxorubicin sensitivity in triple-negative breast cancer cells by targeting MDR1 and JNK and suppressing mTOR and Bcl-2: In vitro and molecular docking study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.22938
Abstract: Multidrug resistance (MDR) is the leading cause of treatment failure in triple-negative breast cancer (TNBC) patients treated with doxorubicin (DXR). We aimed to investigate the potential of the antidiarrheal drug Loperamide (LPR) in sensitizing TNBC… read more here.
Keywords: negative breast; breast cancer; mtor bcl; mdr1 ... See more keywords
TARGETING MULTIDRUG RESISTANCE PROTEIN 1 (MDR1) POTENTIATES SMAC-MIMETIC THERAPY TO KILL LEUKEMIC STEM CELLS AND OVERCOME RESISTANCE IN ACUTE MYELOID LEUKEMIA
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.410
Abstract: Acute myeloid leukemia (AML) is an aggressive disease with a current 5-year survival rate of only ∼25%, therefore development of effective treatments towards resistant AML is urgently needed. Potential mechanisms of therapy resistance include overexpression… read more here.
Keywords: leukemia; acute myeloid; therapy; resistance ... See more keywords
Validation of Human MDR1-MDCK and BCRP-MDCK Cell Lines to Improve the Prediction of Brain Penetration.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.02.005
Abstract: It is of great challenge to predict human brain penetration for substrates of multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP), 2 major efflux transporters at blood-brain barrier. Thus, a physiologically based… read more here.
Keywords: mdck; bcrp; brain penetration; mdr1 ... See more keywords
miR-200c increases the sensitivity of breast cancer cells to Doxorubicin through downregulating MDR1 gene.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2022.104753
Abstract: BACKGROUND Breast cancer (BC) has been known as the most common type of cancer worldwide and resulted in death among women. BC is usually resistant to standard therapies that are significant problems in managing BC… read more here.
Keywords: expression; breast cancer; mdr1; gene ... See more keywords
Multidrug resistance 1 (MDR1/ABCB1) gene polymorphism (rs1045642 C > T) and susceptibility to multiple myeloma: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2018 at "Hematology"
DOI: 10.1080/10245332.2018.1443897
Abstract: ABSTRACT Introduction: Several studies have evaluated the association between the multidrug resistance 1 (MDR1) polymorphism (rs1045642 C > T) and multiple myeloma (MM). However, the results were not consistent. Therefore, to reach a comprehensive and reliable answer… read more here.
Keywords: model; mdr1; polymorphism; meta analysis ... See more keywords
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abn2707
Abstract: Proteolysis-targeting chimeras (PROTACs) are a promising new class of drugs that selectively degrade cellular proteins of interest. PROTACs that target oncogene products are avidly being explored for cancer therapies, and several are currently in clinical… read more here.
Keywords: mdr1; resistance protacs; resistance; drug ... See more keywords
Palmarumycin P3 Reverses Mrr1-Mediated Azole Resistance by Blocking the Efflux Pump Mdr1
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02126-21
Abstract: Palmarumycin P3 (PP3) reduces fluconazole-induced MDR1 transcription to reverse azole resistance in clinical Candida strains. Here, we demonstrated that PP3 restores the susceptibility to several antifungal drugs for Candida albicans strains with gain-of-function mutations in… read more here.
Keywords: albicans strains; palmarumycin; mdr1; azole resistance ... See more keywords
Fast and simple detection methods for the 4–base pair deletion of canine MDR1/ABCB1 gene by PCR and isothermal amplification
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Veterinary Diagnostic Investigation"
DOI: 10.1177/1040638716683213
Abstract: Dogs with a 4-bp deletion in the MDR1 (or ABCB1) gene show intolerance to certain drugs routinely used in veterinary medicine, such as ivermectin, vincristine, and doxorubicin. The mutation leads to a dysfunctional P-glycoprotein drug… read more here.
Keywords: mdr1 abcb1; isothermal amplification; deletion; abcb1 gene ... See more keywords
MDR1 gene polymorphisms and imatinib response in chronic myeloid leukemia: A meta-analysis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Oncology Pharmacy Practice"
DOI: 10.1177/1078155220981150
Abstract: Background Our study aimed to investigate the association between multidrug resistance (MDR1) C1236T, C3435T and G2677T/A polymorphisms and the response to imatinib (IM) in chronic myeloid leukemia (CML). Materials and methods An electronic databases in… read more here.
Keywords: response; mdr1; myeloid leukemia; chronic myeloid ... See more keywords
Prevalence of the MDR1 gene mutation in herding dog breeds and Thai Ridgebacks in Thailand
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary World"
DOI: 10.14202/vetworld.2021.3015-3020
Abstract: Abstract Background and Aim: A canine multi-drug resistance 1 (MDR1) nt230(del4) is a well-known inherited disorder that primarily affects collies and various herding breeds. The most recognized clinical implication for affected dogs is associated with… read more here.
Keywords: dog breeds; mdr1; mdr1 nt230; thai ridgebacks ... See more keywords
SIRT6 Depletion Sensitizes Human Hepatoma Cells to Chemotherapeutics by Downregulating MDR1 Expression
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00194
Abstract: Multidrug resistance (MDR) due to overexpression of MDR1 is a major obstacle that hinders the treatment of hepatocellular carcinoma (HCC). In this study, we explored the function and underlying molecular mechanism of SIRT6 in MDR… read more here.
Keywords: hcc; chemotherapeutic agents; hcc cells; mdr1 ... See more keywords