Treatment-emergent mutations in myelodysplastic syndrome with del(5q) – lenalidomide related or disease-intrinsic clonal evolution?
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DOI: 10.1038/s41408-024-01027-5
Abstract: TO THE EDITOR: Myelodysplastic syndrome (MDS) with del(5q) is a subcategory of MDS without excess blasts ( 22% has been shown to portend inferior overall and leukemia-free survival [2] and, along with therapy-related disease, was… read more here.
Keywords: del lenalidomide; mds del; disease; treatment ... See more keywords
Evolution of severe (transfusion‐dependent) anaemia in myelodysplastic syndromes with 5q deletion is characterized by a macrophage‐associated failure of the eythropoietic niche
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DOI: 10.1111/bjh.18163
Abstract: Evolution of erythrocyte transfusion‐dependent (RBC‐TD) anaemia associated with haploinsufficiency of the ribosomal protein subunit S14 gene (RPS14) is a characteristic complication of myelodysplastic syndromes (MDS) with del(5q) [MDS.del(5q)]. Evaluating 39 patients with MDS.del(5q), read more here.
Keywords: transfusion dependent; myelodysplastic syndromes; anaemia; mds del ... See more keywords
Newly Developed Prognostic Score for Myelodysplastic Syndrome (MDS) with Isolated 5q Deletion (IPSS-del(5q))
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DOI: 10.1182/blood-2024-194405
Abstract: Background & aim: Patients (pts) with MDS-del(5q), including those with TP53 multihit mutations, exhibit better outcomes compared to the general MDS population (Montoro et al., Blood 2024). However, approximately 20% of MDS-del(5q) eventually progress to… read more here.
Keywords: mds del; ipss del; risk; del ... See more keywords
Refining the prognostic hierarchy of TP53 multihit alterations and isolated deletion of chromosome 5q in myelodysplastic syndromes
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DOI: 10.1182/blood-2025-2068
Abstract: Background & aim: Myelodysplastic syndromes with isolated deletion of chromosome 5q (MDS-del(5q)) are associated with low-risk features and favorable prognosis. In contrast, TP53 multihit alterations, typically reflecting biallelic inactivation, are associated with high-risk features and… read more here.
Keywords: mds tp53; mds del; tp53; tp53 multihit ... See more keywords
Influence of TP53 Gene Mutations and its Allelic Status in Myelodysplastic Syndromes with Isolated 5q Deletion.
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DOI: 10.1182/blood.2024023840
Abstract: Mutations in the TP53 gene, particularly multihit alterations, have been associated with unfavorable clinical features and prognosis in patients diagnosed with myelodysplastic syndrome (MDS). Despite this, the role of TP53 gene aberrations in MDS with… read more here.
Keywords: mds del; mutations allelic; isolated deletion; tp53 gene ... See more keywords