Rituximab, bendamustine and cytarabine (R‐BAC) in patients with relapsed‐refractory aggressive B‐cell lymphoma
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DOI: 10.1002/ajh.25278
Abstract: and bone marrow mast cell burden (Table 1). Next, we focused on SM-AHN-myeloid (n = 178), which included 11 (6%) patients with SM associated with acute myeloid leukemia (SM-AML), 50 (28%) patients with SM associated… read more here.
Keywords: cell; patients associated; ahn myeloid; mds mpn ... See more keywords
1004 - HOW DO SRSF2P95H MUTATIONS LEAD TO MYELODYSPLASTIC/MYELOPROLIFERATIVE SYNDROME (MDS/MPN)?
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.242
Abstract: SRSF2 P95 mutations are prevalent in myelodysplastic (MDS) and myelodysplastic/myeloproliferative (MDS/MPN) syndromes. They occur early in the course of the disease, are positively selected during disease progression and are associated with poor outcomes. Understanding how… read more here.
Keywords: mds; myelodysplastic myeloproliferative; mds mpn; srsf2p95h ... See more keywords
3q26/EVI1 rearrangement in myelodysplastic/myeloproliferative neoplasms: An early event associated with a poor prognosis.
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DOI: 10.1016/j.leukres.2017.12.004
Abstract: 3q26.2/EVI1 rearrangements resulting in EVI1 overexpression play an important role in leukemogenesis and are associated with treatment resistance and a poorer prognosis in patients with acute myeloid leukemia, myelodysplastic syndrome, chronic myeloid leukemia and BCR-ABL… read more here.
Keywords: 3q26 evi1; prognosis; myelodysplastic myeloproliferative; evi1 rearrangements ... See more keywords
Spectrum of abnormalities and clonal transformation in germline RUNX1 familial platelet disorder and a genomic comparative analysis with somatic RUNX1 mutations in MDS/MPN overlap neoplasms
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DOI: 10.1038/s41375-020-0752-x
Abstract: The Runt-related transcription factor 1 (RUNX1) gene encodes a transcription factor that plays a crucial role in embryogenesis and definitive hematopoiesis [1]. Germline RUNX1 mutations (RUNX1) result in a familial platelet disorder with propensity to… read more here.
Keywords: germline runx1; somatic runx1; runx1; mpn overlap ... See more keywords
Myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T): Mayo-Moffitt collaborative study of 158 patients
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DOI: 10.1038/s41408-022-00622-8
Abstract: The current World Health Organization (WHO) classification of myeloid malignancies includes myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) as a distinct entity. Previous literature on predictors of survival was based on the provisional category… read more here.
Keywords: thrombocytosis; mds mpn; myeloproliferative neoplasms; myelodysplastic myeloproliferative ... See more keywords
Genomics of myelodysplastic/myeloproliferative neoplasm.
Sign Up to like & getrecommendations! Published in 2023 at "Seminars in diagnostic pathology"
DOI: 10.1053/j.semdp.2023.04.005
Abstract: Myelodysplastic/ Myeloproliferative neoplasms (MDS/MPN) demonstrate overlapping pathologic and molecular features of myelodysplastic (MDS) and myeloproliferative (MPN) neoplasms. Diagnosis is difficult based on morphology alone, requiring exclusion of various non-neoplastic causes for CBC abnormalities and morphologic… read more here.
Keywords: genomics myelodysplastic; classification; myeloproliferative neoplasm; mds mpn ... See more keywords
Genetic mutations associated with blood count abnormalities in myeloid neoplasms
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DOI: 10.1080/16078454.2022.2094134
Abstract: ABSTRACT Introduction Myelodysplastic syndromes (MDS) predominantly present with varying degrees of cytopenia, while myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) exhibit proliferative features. Genetic defects underlying different complete blood count (CBC) alterations remain to be defined. Objective We… read more here.
Keywords: mds; mds mpn; risk mds; blood ... See more keywords
MDS/MPN with ring sideroblasts and thrombocytosis masquerading as prefibrotic/early primary myelofibrosis.
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DOI: 10.1182/blood-2016-11-749937
Abstract: ![Figure][1] A 75-year-old man was investigated for persistent thrombocytosis/leukocytosis. He had history of night sweats and chronic anemia, but no thrombotic events. He had no splenomegaly and lactate dehydrogenase was persistently elevated (380 U/L). Complete… read more here.
Keywords: mpn ring; ring sideroblasts; thrombocytosis; thrombocytosis masquerading ... See more keywords
Clinical Impact of an Accurate Genetic Characterization of Older Acute Myeloid Leukemia Patients: A Report from the Northern Italy Leukemia Group (NILG) Randomized Trial 02/06
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DOI: 10.1182/blood-2018-99-113869
Abstract: Introduction In acute myeloid leukemia (AML) older age is independently associated with poor outcome, due to patient- and disease-related factors. Different genetic profiles characterize AML patients and their frequency varies according to age. Their identification… read more here.
Keywords: risk; aml patients; leukemia; consultancy ... See more keywords
Characteristics and Role of Lenalidomide Therapy in Patients with Myelodysplastic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis
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DOI: 10.1182/blood-2018-99-117266
Abstract: Introduction: Myelodysplastic/Myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T), previously known as RARS-T is now recognized as a full entity in the 2016 World Health Organization classification of myeloid neoplasms and acute leukemia. It is… read more here.
Keywords: thrombocytosis; disease; mds mpn; lenalidomide therapy ... See more keywords
Functional Interrogation of Variants of Undetermined Significance of the Isocitrate Dehydrogenase 1 and 2 Genes in Myeloid Neoplasms
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DOI: 10.1182/blood-2019-128067
Abstract: Introduction: Isocitrate dehydrogenase 1 and 2 (IDH1/2) are metabolic enzymes in the citric acid cycle, producing alpha-ketoglutarate (αKG). Mutations in specific regions of these genes have been characterized in gliomas, AML and chronic myeloid neoplasms… read more here.
Keywords: isocitrate dehydrogenase; idhvus; significance; mds ... See more keywords