RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS
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DOI: 10.1182/bloodadvances.2022007804
Abstract: Key Points • Coexistence of the Srsf2 P95H mutation and Runx1 deficiency recapitulates the multilineage hematopoietic defects observed in MDS.• RUNX1 deficiency strikingly alters global splicing patterns and synergizes with the Srsf2 P95H mutation to… read more here.
Keywords: runx1 deficiency; multilineage hematopoietic; hematopoietic defects; mds runx1 ... See more keywords