Targeted deletion of HIF-1α in myeloid cells of neonatal mice: decreased accumulation of myeloid-derived suppressor cells and altered microbiome.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250144
Abstract: The newborn's immune system is faced with the challenge of having to learn quickly to fight off infectious agents, but tolerating the colonization of the body surfaces with commensals without reacting with an excessive inflammatory… read more here.
Keywords: myeloid derived; suppressor cells; hif; myeloid ... See more keywords
The role of myeloid derived suppressor cells in mycosis fungoides
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-018-2153-9
Abstract: We have read with interest the recent publication “Thera‐ peutic reduction of cell‐mediated immunosuppression in mycosis fungoides and Sézary syndrome” by Geskin et al. [1] and would like to comment on it based on our… read more here.
Keywords: derived suppressor; mycosis fungoides; mdsc; role ... See more keywords
Structural characterization of a pectin-type polysaccharide from Curcuma kwangsiensis and its effects on reversing MDSC-mediated T cell suppression.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.04.153
Abstract: Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play a major role in tumor-induced immunosuppression. The potent modulatory effects of polysaccharides on the innate and adaptive immune system stimulate antitumor responses. In this study,… read more here.
Keywords: pectin type; mdsc mediated; mediated cell; mdsc ... See more keywords
Differential Content of Proteins, mRNAs, and miRNAs Suggests that MDSC and Their Exosomes May Mediate Distinct Immune Suppressive Functions.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.7b00646
Abstract: Myeloid-derived suppressor cells (MDSC) are immature myeloid cells that accumulate in the circulation and the tumor microenvironment of most cancer patients. There, MDSC suppress both adaptive and innate immunity, hindering immunotherapies. The inflammatory milieu often… read more here.
Keywords: mdsc exosomes; mdsc suppressive; exosomes may; mdsc ... See more keywords
Myeloid-derived suppressor cell subtypes differentially influence T-cell function, T-helper subset differentiation, and clinical course in CLL
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01249-7
Abstract: Cancer pathogenesis involves the interplay of tumor- and microenvironment-derived stimuli. Here we focused on the influence of an immunomodulatory cell type, myeloid-derived suppressor cells (MDSCs), and their lineage-related subtypes on autologous T lymphocytes. Although MDSCs… read more here.
Keywords: clinical course; mdscs; mdsc; course ... See more keywords
Exploring the Relationship Between Circulating M-MDSC Numbers and Risk of Posttransplant Malignancy - Commentary on Utrero-Rico et al.
Sign Up to like & getrecommendations! Published in 2020 at "Transplantation"
DOI: 10.1097/tp.0000000000003180
Abstract: I the current issue of Transplantation, Utrero-Rico et al report an association between risk of posttransplant malignancy and peak monocytic myeloid-derived suppressor cell (M-MDSC) responses early after renal transplantation. This is an important clinical observation… read more here.
Keywords: utrero rico; circulating mdsc; mdsc; posttransplant malignancy ... See more keywords
Monocytic myeloid‐derived suppressor cells as prognostic factor in chronic myeloid leukaemia patients treated with dasatinib
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13326
Abstract: Myeloid suppressor cells are a heterogeneous group of myeloid cells that are increased in patients with chronic myeloid leukaemia (CML) inducing T cell tolerance. In this study, we found that therapy with tyrosine kinase inhibitors… read more here.
Keywords: treated dasatinib; medicine; suppressor cells; patients treated ... See more keywords
Peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in AML patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17576
Abstract: Myeloid Derived Suppressive Cells (MDSC) are capable to suppress innate and adaptive immune responses, thus favouring solid cancer progression. However, little is known about the role of MDSC in acute myeloid leukaemia (AML). In this… read more here.
Keywords: derived suppressive; myeloid derived; aml patients; suppressive cells ... See more keywords
Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-001223
Abstract: Background Myeloid-derived suppressor cells (MDSC) are a functional myeloid cell subset that includes myeloid cells with immune suppressive properties. The presence of MDSC has been reported in the peripheral blood of patients with several malignant… read more here.
Keywords: mdsc subsets; expansion; infection; inflammation ... See more keywords
STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004384
Abstract: Background Myeloid-derived suppressor cells (MDSCs) represent a negative prognostic factor in malignant melanoma. These cells are generated under chronic inflammatory conditions typical of cancer. The transcription factor signal transducer and activator of transcription 3 (STAT3)… read more here.
Keywords: capacity; stat3; melanoma bearing; mdsc ... See more keywords
AMPK alpha-1 intrinsically regulates the function and differentiation of tumor myeloid-derived suppressor cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-19-0880
Abstract: Myeloid-derived suppressor cells (MDSC) represent a primary mechanism of immune evasion in tumors and have emerged as a major obstacle for cancer immunotherapy. The immunoinhibitory activity of MDSC is tightly regulated by the tumor microenvironment… read more here.
Keywords: myeloid; mdsc; cancer; tumor ... See more keywords