Targeted deletion of HIF-1α in myeloid cells of neonatal mice: decreased accumulation of myeloid-derived suppressor cells and altered microbiome.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250144
Abstract: The newborn's immune system is faced with the challenge of having to learn quickly to fight off infectious agents, but tolerating the colonization of the body surfaces with commensals without reacting with an excessive inflammatory… read more here.
Keywords: myeloid derived; suppressor cells; hif; myeloid ... See more keywords
Delineation of monocytic and early‐stage myeloid‐derived suppressor cells in the peripheral blood of patients with hepatocarcinoma
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Cancer"
DOI: 10.1002/ijc.35390
Abstract: In patients with hepatocellular carcinoma (HCC), increased myeloid‐derived suppressor cells (MDSC) relate to aggressiveness and poor prognosis. Favorable responses with immune checkpoint inhibitors demonstrate that HCC is susceptible to immune activation, suggesting that the elimination… read more here.
Keywords: derived suppressor; mdsc; suppressor cells; emdsc ... See more keywords
The role of myeloid derived suppressor cells in mycosis fungoides
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-018-2153-9
Abstract: We have read with interest the recent publication “Thera‐ peutic reduction of cell‐mediated immunosuppression in mycosis fungoides and Sézary syndrome” by Geskin et al. [1] and would like to comment on it based on our… read more here.
Keywords: derived suppressor; mycosis fungoides; mdsc; role ... See more keywords
Structural characterization of a pectin-type polysaccharide from Curcuma kwangsiensis and its effects on reversing MDSC-mediated T cell suppression.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.04.153
Abstract: Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play a major role in tumor-induced immunosuppression. The potent modulatory effects of polysaccharides on the innate and adaptive immune system stimulate antitumor responses. In this study,… read more here.
Keywords: pectin type; mdsc mediated; mediated cell; mdsc ... See more keywords
Differential Content of Proteins, mRNAs, and miRNAs Suggests that MDSC and Their Exosomes May Mediate Distinct Immune Suppressive Functions.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.7b00646
Abstract: Myeloid-derived suppressor cells (MDSC) are immature myeloid cells that accumulate in the circulation and the tumor microenvironment of most cancer patients. There, MDSC suppress both adaptive and innate immunity, hindering immunotherapies. The inflammatory milieu often… read more here.
Keywords: mdsc exosomes; mdsc suppressive; exosomes may; mdsc ... See more keywords
Myeloid-derived suppressor cell subtypes differentially influence T-cell function, T-helper subset differentiation, and clinical course in CLL
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01249-7
Abstract: Cancer pathogenesis involves the interplay of tumor- and microenvironment-derived stimuli. Here we focused on the influence of an immunomodulatory cell type, myeloid-derived suppressor cells (MDSCs), and their lineage-related subtypes on autologous T lymphocytes. Although MDSCs… read more here.
Keywords: clinical course; mdscs; mdsc; course ... See more keywords
CD44 expression on murine hepatic stellate cells promotes the induction of monocytic and polymorphonuclear myeloid-derived suppressor cells.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiae053
Abstract: In chronic inflammation regulatory immune cells, such as regulatory T cells and myeloid-derived suppressor cells (MDCS) can develop. Local signals in the inflamed tissue, such as cytokines and eicosanoids, but also contact dependent signals, can… read more here.
Keywords: pmn mdsc; mdsc; stellate cells; cd44 ... See more keywords
IMMU-57. In vivo targeting of primary cilia attenuates immunosuppression in glioblastoma via MDSC regulation
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.0855
Abstract: Glioblastoma is an aggressive brain tumor characterized by its complex Microenvironment and profound immune suppression. Recent studies have highlighted the involvement of primary cilia in various cellular processes, including the modulation of the tumor microenvironment.… read more here.
Keywords: mdsc; microenvironment; glioblastoma; primary cilia ... See more keywords
Exploring the Relationship Between Circulating M-MDSC Numbers and Risk of Posttransplant Malignancy - Commentary on Utrero-Rico et al.
Sign Up to like & getrecommendations! Published in 2020 at "Transplantation"
DOI: 10.1097/tp.0000000000003180
Abstract: I the current issue of Transplantation, Utrero-Rico et al report an association between risk of posttransplant malignancy and peak monocytic myeloid-derived suppressor cell (M-MDSC) responses early after renal transplantation. This is an important clinical observation… read more here.
Keywords: utrero rico; circulating mdsc; mdsc; posttransplant malignancy ... See more keywords
Monocytic myeloid‐derived suppressor cells as prognostic factor in chronic myeloid leukaemia patients treated with dasatinib
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13326
Abstract: Myeloid suppressor cells are a heterogeneous group of myeloid cells that are increased in patients with chronic myeloid leukaemia (CML) inducing T cell tolerance. In this study, we found that therapy with tyrosine kinase inhibitors… read more here.
Keywords: treated dasatinib; medicine; suppressor cells; patients treated ... See more keywords
Peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in AML patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17576
Abstract: Myeloid Derived Suppressive Cells (MDSC) are capable to suppress innate and adaptive immune responses, thus favouring solid cancer progression. However, little is known about the role of MDSC in acute myeloid leukaemia (AML). In this… read more here.
Keywords: derived suppressive; myeloid derived; aml patients; suppressive cells ... See more keywords