Monocytic myeloid‐derived suppressor cells regulate T‐cell responses against vaccinia virus
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646797
Abstract: Vaccinia virus (VV) can potently activate NK‐ and T‐cell responses, leading to efficient viral control and generation of long‐lasting protective immunity. However, immune responses against viral infections are often tightly controlled to avoid collateral damage… read more here.
Keywords: myeloid derived; cell responses; infection; mdscs ... See more keywords
MDSCs drive the process of endometriosis by enhancing angiogenesis and are a new potential therapeutic target
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747417
Abstract: Endometriosis affects women of reproductive age via unclear immunological mechanism(s). Myeloid‐derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells with potent immunosuppressive and angiogenic properties. Here, we found MDSCs significantly increased in the… read more here.
Keywords: endometriosis; drive process; target; mdscs ... See more keywords
HDAC11 regulates expression of C/EBPβ and immunosuppressive molecules in myeloid‐derived suppressor cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1a1119-606rrr
Abstract: Myeloid‐derived suppressor cells (MDSCs) constitute a heterogeneous population of immature myeloid cells derived from bone marrow and negatively regulate both innate and adaptive immunity in the tumor microenvironment. Previously we have demonstrated that MDSCs lacking… read more here.
Keywords: expression; myeloid derived; hdac11; immunosuppressive molecules ... See more keywords
Decitabine shows potent anti-myeloma activity by depleting monocytic myeloid-derived suppressor cells in the myeloma microenvironment
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-018-2790-6
Abstract: PurposeMultiple myeloma (MM) remains incurable. The MM microenvironment supports MM cells’ survival and immune escape. Because myeloid-derived suppressor cells (MDSCs) is important in the MM microenvironment, and demethylating agent decitabine (DAC) can deplete MDSCs in… read more here.
Keywords: microenvironment; dac; myeloma; treatment ... See more keywords
CCR4+ monocytic myeloid-derived suppressor cells are associated with the increased epithelial-mesenchymal transition in pancreatic adenocarcinoma patients.
Sign Up to like & getrecommendations! Published in 2022 at "Immunobiology"
DOI: 10.1016/j.imbio.2022.152210
Abstract: Among all the cancer-related deaths globally, pancreatic ductal adenocarcinoma (PDAC) accounts for the seventh leading cause of mortality. A dysregulated immune system disrupts anti-tumor immunity by abnormal accumulation of myeloid-derived suppressor cells (MDSCs), but the… read more here.
Keywords: tumor; mesenchymal transition; mdscs; ccr4 ... See more keywords
Impaired myeloid-derived suppressor cells are associated with recurrent implantation failure: A case-control study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of reproductive immunology"
DOI: 10.1016/j.jri.2021.103316
Abstract: BACKGROUND Studies have reported that myeloid-derived suppressor cells (MDSCs) contribute to maintain pregnancy. The aim of this case-control study was to test whether there is a dysregulation of peripheral MDSCs in recurrent implantation failure (RIF).… read more here.
Keywords: suppressor cells; derived suppressor; mdscs; pmn mdscs ... See more keywords
Bevacizumab Reduces S100A9‐Positive MDSCs Linked to Intracranial Control in Patients with EGFR‐Mutant Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2018.03.032
Abstract: Introduction: In vitro models have demonstrated immune‐modulating effects of bevacizumab (BEV). Combinations of an EGFR tyrosine kinase inhibitor (TKI) with BEV improve progression‐free survival (PFS) in patients with EGFR‐mutated lung adenocarcinoma. How BEV confers this… read more here.
Keywords: lung adenocarcinoma; mdscs; bev; tki group ... See more keywords
Analysis of therapeutic potential of monocytic myeloid-derived suppressor cells in cardiac allotransplantation.
Sign Up to like & getrecommendations! Published in 2021 at "Transplant immunology"
DOI: 10.1016/j.trim.2021.101405
Abstract: BACKGROUND Myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) are attractive immune cells to induce immune tolerance. To explore a strategy for improving the efficacy of MDSC therapies, we examined the impact of adoptive… read more here.
Keywords: suppressor cells; derived suppressor; graft survival; graft ... See more keywords
Myeloid-derived suppressor cell subtypes differentially influence T-cell function, T-helper subset differentiation, and clinical course in CLL
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01249-7
Abstract: Cancer pathogenesis involves the interplay of tumor- and microenvironment-derived stimuli. Here we focused on the influence of an immunomodulatory cell type, myeloid-derived suppressor cells (MDSCs), and their lineage-related subtypes on autologous T lymphocytes. Although MDSCs… read more here.
Keywords: clinical course; mdscs; mdsc; course ... See more keywords
Interleukin-10 produced by myeloid-derived suppressor cells is critical for the induction of Tregs and attenuation of rheumatoid inflammation in mice
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-21856-2
Abstract: Myeloid-derived suppressor cells (MDSCs) are heterogenous populations of immature myeloid progenitor cells with immunoregulatory function. MDSCs play critical roles in controlling the processes of autoimmunity but their roles in rheumatoid arthritis (RA) are controversial. The… read more here.
Keywords: suppressor cells; derived suppressor; mdscs; mice ... See more keywords
Pseudolycorine chloride ameliorates Th17 cell-mediated central nervous system autoimmunity by restraining myeloid-derived suppressor cell expansion
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2063344
Abstract: Abstract Context The alkaloids of Narcissus tazetta L. var. Chinensis Roem (Amaryllidaceae) have antitumor and antiviral activities. However, the immunopharmacological effects of one of its constituents, pseudolycorine chloride (PLY), have not been reported yet. Objective… read more here.
Keywords: cell; ply; mdscs; myeloid derived ... See more keywords