Revisiting cellular immune response to oncogenic Marek’s disease virus: the rising of avian T-cell immunity
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03477-z
Abstract: Marek’s disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes deadly T-cell lymphomas and serves as a natural virus-induced tumor model in chickens. Although Marek’s disease (MD) is well controlled by current vaccines, the… read more here.
Keywords: marek disease; immunity; mdv; cell ... See more keywords
Immunogenicity and safety of 13-valent pneumococcal conjugate vaccine (PCV13) formulated with 2-phenoxyethanol in multidose vials given with routine vaccination in healthy infants: An open-label randomized controlled trial.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.04.049
Abstract: BACKGROUND This open-label randomized controlled trial in infants compared safety, tolerability, and immunogenicity of the 13-valent pneumococcal conjugate vaccine (PCV13) formulated with the preservative 2-phenoxyethanol (2-PE) in a multidose vial (MDV) to the current PCV13… read more here.
Keywords: immunogenicity; trial; safety; pcv13 ... See more keywords
Differential expression of type I interferon mRNA and protein levels induced by virulent Marek's disease virus infection in chickens.
Sign Up to like & getrecommendations! Published in 2019 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2019.04.010
Abstract: Marek's disease virus (MDV), an α-herpesvirus targeting avian species, causes fatal Marek's disease (MD) in chickens. The host interferon (IFN) responses play a key role in resisting viral infection. However, host IFN responses following MDV… read more here.
Keywords: expression; marek disease; infection; mdv ... See more keywords
Detailed molecular investigation of Marek's disease virus circulating in organised poultry farms in India revealed emergence of highly virulent MDV causing varied tissue tropism.
Sign Up to like & getrecommendations! Published in 2025 at "British poultry science"
DOI: 10.1080/00071668.2025.2557471
Abstract: 1. The current study analysed Marek's Disease virus (MDV) strains, genome characteristics and associated pathology, with reference to the central nervous system, in naturally occurring field cases across India.2. A total of 179 birds, aged… read more here.
Keywords: disease; mdv; brain; virulent mdv ... See more keywords
Shotgun metagenomics reveal a diverse assemblage of protists in a model Antarctic soil ecosystem.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental microbiology"
DOI: 10.1111/1462-2920.15198
Abstract: The soils of the McMurdo Dry Valleys (MDV) of Antarctica are established models for understanding fundamental processes in soil ecosystem functioning (e.g. ecological tipping points, community structuring, and nutrient cycling) because the extreme physical environment… read more here.
Keywords: ecosystem; soil ecosystem; biodiversity; soil ... See more keywords
The Marek's Disease Virus Unique Gene MDV082 Is Dispensable for Virus Replication but Contributes to a Rapid Disease Onset
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.00131-21
Abstract: MDV is a highly oncogenic alphaherpesvirus that causes Marek’s disease in chickens. The virus causes immense economic losses in the poultry industry due to the high morbidity and mortality, but also the cost of the… read more here.
Keywords: marek disease; mdv082 protein; virus; disease ... See more keywords
Inhibition of DNA-Sensing Pathway by Marek's Disease Virus VP23 Protein through Suppression of Interferon Regulatory Factor 7 Activation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01934-18
Abstract: Despite widespread vaccination, Marek’s disease (MD) continues to pose major challenges for the poultry industry worldwide. MDV causes immunosuppression and deadly lymphomas in chickens, suggesting that this virus has developed a successful immune evasion strategy.… read more here.
Keywords: vp23; response; dna; activation ... See more keywords
Marek’s disease virus-encoded microRNA-M6-5p facilitates viral latent infection by targeting histone demethylase KDM2B
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Virology"
DOI: 10.1128/jvi.02007-24
Abstract: ABSTRACT Marek’s disease virus (MDV), a highly contagious and oncogenic avian alphaherpesvirus, establishes a latent infection primarily in CD4+ T cells. Latent infections are necessary for both persistent lifelong MDV infection and viral tumorigenesis. MicroRNAs… read more here.
Keywords: virus encoded; mdv; infection; latency ... See more keywords
Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors
Sign Up to like & getrecommendations! Published in 2019 at "mSphere"
DOI: 10.1128/msphere.00569-18
Abstract: Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus that infects chickens and causes the most frequent clinically diagnosed cancer in the animal kingdom. Not only is MDV an important pathogen that threatens the poultry industry… read more here.
Keywords: mdv; mass spectrometry; virus; mdv induced ... See more keywords
Genetic characterization of a Marek’s disease virus strain isolated in Japan
Sign Up to like & getrecommendations! Published in 2020 at "Virology Journal"
DOI: 10.1186/s12985-020-01456-1
Abstract: Background Marek’s disease virus (MDV) causes malignant lymphomas in chickens (Marek’s disease, MD). MD is currently controlled by vaccination; however, MDV strains have a tendency to develop increased virulence. Distinct diversity and point mutations are… read more here.
Keywords: marek disease; mdv; mdv strains; disease virus ... See more keywords
Two distinct polymorphisms in the basic region of Meq protein of marek’s disease virus alter pathological progression and clinical manifestations
Sign Up to like & getrecommendations! Published in 2025 at "Virology Journal"
DOI: 10.1186/s12985-025-02930-4
Abstract: Marek’s disease virus (MDV) causes Marek’s disease (MD) in chickens, which is characterized by malignant lymphomas and neurological disorders. Although MD is currently controlled using live vaccines, the virulence of field strains has continuously increased… read more here.
Keywords: marek disease; basic region; mdv; virulence ... See more keywords