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   Articles with "mdx" as a keyword



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Differential expression of Triggering Receptor Expressed on Myeloid cells 2 (Trem2) in tissue eosinophils

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recommendations! Published in 2021 at "Journal of Leukocyte Biology"

DOI: 10.1002/jlb.3a0920-620r

Abstract: No longer regarded simply as end‐stage cytotoxic effectors, eosinophils are now recognized as complex cells with unique phenotypes that develop in response stimuli in the local microenvironment. In our previous study, we documented eosinophil infiltration… read more here.

Keywords: expression; mice; muscle; mdx ... See more keywords

Enhancing Endogenous Nitric Oxide by Whole Body Periodic Acceleration Elicits Neuroprotective Effects in Dystrophic Neurons

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recommendations! Published in 2018 at "Molecular Neurobiology"

DOI: 10.1007/s12035-018-1018-8

Abstract: We have previously shown that inadequate dystrophin in cortical neurons in mdx mice is associated with age-dependent dyshomeostasis of resting intracellular Ca2+ ([Ca2+]i) and Na+ ([Na+]i), elevated reactive oxygen species (ROS) production, increase in neuronal… read more here.

Keywords: body periodic; mdx neurons; mdx; nitric oxide ... See more keywords

Blockade of Bradykinin receptors worsens the dystrophic phenotype of mdx mice: differential effects for B1 and B2 receptors

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recommendations! Published in 2017 at "Journal of Cell Communication and Signaling"

DOI: 10.1007/s12079-017-0439-x

Abstract: The Kallikrein Kinin System (KKS) is a vasoactive peptide system with known functions in the maintenance of tissue homeostasis, renal function and blood pressure. The main effector peptide of KKS is Bradykinin (BK). This ligand… read more here.

Keywords: receptors worsens; worsens dystrophic; mdx mice; mdx ... See more keywords

Social stress is lethal in the mdx model of Duchenne muscular dystrophy

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recommendations! Published in 2020 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2020.102700

Abstract: Background Duchenne muscular dystrophy (DMD) is caused by the loss of dystrophin. Severe and ultimately lethal, DMD progresses relatively slowly in that patients become wheelchair bound only around age twelve with a survival expectancy reaching… read more here.

Keywords: mdx mice; muscular dystrophy; stress; mdx ... See more keywords

Hyperbaric therapy provides no benefit for skeletal muscle and respiratory function and accelerates cardiac injury in mdx mice

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-48744-7

Abstract: Duchenne muscular dystrophy (DMD) is a uniformly fatal condition of striated muscle wasting resulting in premature death from respiratory and/or cardiac failure. Symptomatic therapy has prolonged survival by limiting deaths resulting from respiratory insufficiency, but… read more here.

Keywords: therapy; muscle; function; mdx ... See more keywords

Reduced Na current in dystrophin-deficient ventricular cardiomyocytes is rescued by tenascin-C inhibition

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recommendations! Published in 2024 at "European Heart Journal"

DOI: 10.1093/eurheartj/ehae666.3776

Abstract: Duchenne muscular dystrophy (DMD) is an X-linked hereditary disease triggered by the deficiency of the structural protein dystrophin, which leads to muscular degeneration mainly affecting young males. Major contributors to early death in DMD patients… read more here.

Keywords: mdx; dmd; dystrophin deficient; inhibition ... See more keywords

Decreasing microtubule detyrosination by parthenolide restores sodium current in mdx cardiomyocytes

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recommendations! Published in 2023 at "Europace"

DOI: 10.1093/europace/euad122.592

Abstract: Abstract Funding Acknowledgements Type of funding sources: None. Background The cardiac sodium channel Nav1.5 is transported to the membrane by the microtubule network. Alterations in microtubule dynamics are known to impact on ion channel trafficking.… read more here.

Keywords: microtubule detyrosination; parthenolide; mdx; cms ... See more keywords

Cerebellar dysfunction in the mdx mouse model of Duchenne muscular dystrophy: An electrophysiological and behavioural study

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recommendations! Published in 2024 at "European Journal of Neuroscience"

DOI: 10.1111/ejn.16566

Abstract: Patients with Duchenne muscular dystrophy (DMD) commonly show specific cognitive deficits in addition to a severe muscle impairment caused by the absence of dystrophin expression in skeletal muscle. These cognitive deficits have been related to… read more here.

Keywords: duchenne muscular; mdx; muscular dystrophy; cerebellar dysfunction ... See more keywords

Cilostazol attenuates oxidative stress and apoptosis in the quadriceps muscle of the dystrophic mouse experimental model

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recommendations! Published in 2022 at "International Journal of Experimental Pathology"

DOI: 10.1111/iep.12461

Abstract: Duchenne muscular dystrophy (DMD) is the most severe and frequent form of muscular dystrophy. The mdx mouse is one of the most widely used experimental models to understand aspects of the biology of dystrophic skeletal… read more here.

Keywords: mdx mice; mdx; oxidative stress; muscle ... See more keywords

Chronic N‐acetyl cysteine treatment does not improve respiratory system performance in the mdx mouse model of Duchenne muscular dystrophy

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recommendations! Published in 2024 at "Experimental Physiology"

DOI: 10.1113/ep091862

Abstract: Duchenne muscular dystrophy (DMD) is characterised by respiratory muscle injury, inflammation, fibrosis and weakness, ultimately culminating in respiratory failure. The dystrophin‐deficient mouse model of DMD (mdx) shows evidence of respiratory muscle remodelling and dysfunction contributing… read more here.

Keywords: treatment; mdx; respiratory system; performance ... See more keywords

Voluntary wheel running and lithium supplementation improves muscle force production without altering SERCA function in the D2 mdx mouse

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5730580

Abstract: Background: Duchenne muscular dystrophy (DMD) is an X-linked recessive muscle wasting disease that, with no cure, leads to early mortality (30-40 years of age). Previous studies have shown that voluntary wheel running can mitigate disease… read more here.

Keywords: serca function; mdx; muscle; physiology ... See more keywords