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   Articles with "mdx" as a keyword



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Differential expression of Triggering Receptor Expressed on Myeloid cells 2 (Trem2) in tissue eosinophils

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recommendations! Published in 2021 at "Journal of Leukocyte Biology"

DOI: 10.1002/jlb.3a0920-620r

Abstract: No longer regarded simply as end‐stage cytotoxic effectors, eosinophils are now recognized as complex cells with unique phenotypes that develop in response stimuli in the local microenvironment. In our previous study, we documented eosinophil infiltration… read more here.

Keywords: expression; mice; muscle; mdx ... See more keywords
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Enhancing Endogenous Nitric Oxide by Whole Body Periodic Acceleration Elicits Neuroprotective Effects in Dystrophic Neurons

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recommendations! Published in 2018 at "Molecular Neurobiology"

DOI: 10.1007/s12035-018-1018-8

Abstract: We have previously shown that inadequate dystrophin in cortical neurons in mdx mice is associated with age-dependent dyshomeostasis of resting intracellular Ca2+ ([Ca2+]i) and Na+ ([Na+]i), elevated reactive oxygen species (ROS) production, increase in neuronal… read more here.

Keywords: body periodic; mdx neurons; mdx; nitric oxide ... See more keywords
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Blockade of Bradykinin receptors worsens the dystrophic phenotype of mdx mice: differential effects for B1 and B2 receptors

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recommendations! Published in 2017 at "Journal of Cell Communication and Signaling"

DOI: 10.1007/s12079-017-0439-x

Abstract: The Kallikrein Kinin System (KKS) is a vasoactive peptide system with known functions in the maintenance of tissue homeostasis, renal function and blood pressure. The main effector peptide of KKS is Bradykinin (BK). This ligand… read more here.

Keywords: receptors worsens; worsens dystrophic; mdx mice; mdx ... See more keywords
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Social stress is lethal in the mdx model of Duchenne muscular dystrophy

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recommendations! Published in 2020 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2020.102700

Abstract: Background Duchenne muscular dystrophy (DMD) is caused by the loss of dystrophin. Severe and ultimately lethal, DMD progresses relatively slowly in that patients become wheelchair bound only around age twelve with a survival expectancy reaching… read more here.

Keywords: mdx mice; muscular dystrophy; stress; mdx ... See more keywords
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Hyperbaric therapy provides no benefit for skeletal muscle and respiratory function and accelerates cardiac injury in mdx mice

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-48744-7

Abstract: Duchenne muscular dystrophy (DMD) is a uniformly fatal condition of striated muscle wasting resulting in premature death from respiratory and/or cardiac failure. Symptomatic therapy has prolonged survival by limiting deaths resulting from respiratory insufficiency, but… read more here.

Keywords: therapy; muscle; function; mdx ... See more keywords

Decreasing microtubule detyrosination by parthenolide restores sodium current in mdx cardiomyocytes

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recommendations! Published in 2023 at "Europace"

DOI: 10.1093/europace/euad122.592

Abstract: Abstract Funding Acknowledgements Type of funding sources: None. Background The cardiac sodium channel Nav1.5 is transported to the membrane by the microtubule network. Alterations in microtubule dynamics are known to impact on ion channel trafficking.… read more here.

Keywords: microtubule detyrosination; parthenolide; mdx; cms ... See more keywords
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Cilostazol attenuates oxidative stress and apoptosis in the quadriceps muscle of the dystrophic mouse experimental model

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recommendations! Published in 2022 at "International Journal of Experimental Pathology"

DOI: 10.1111/iep.12461

Abstract: Duchenne muscular dystrophy (DMD) is the most severe and frequent form of muscular dystrophy. The mdx mouse is one of the most widely used experimental models to understand aspects of the biology of dystrophic skeletal… read more here.

Keywords: mdx mice; mdx; oxidative stress; muscle ... See more keywords
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Voluntary wheel running and lithium supplementation improves muscle force production without altering SERCA function in the D2 mdx mouse

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5730580

Abstract: Background: Duchenne muscular dystrophy (DMD) is an X-linked recessive muscle wasting disease that, with no cure, leads to early mortality (30-40 years of age). Previous studies have shown that voluntary wheel running can mitigate disease… read more here.

Keywords: serca function; mdx; muscle; physiology ... See more keywords
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Role of miR-200c in Myogenic Differentiation Impairment via p66Shc: Implication in Skeletal Muscle Regeneration of Dystrophic mdx Mice

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recommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2018/4814696

Abstract: Duchenne muscular dystrophy (DMD) is a genetic disease associated with mutations of Dystrophin gene that regulate myofiber integrity and muscle degeneration, characterized by oxidative stress increase. We previously published that reactive oxygen species (ROS) induce… read more here.

Keywords: skeletal muscle; myogenic differentiation; muscle; mdx ... See more keywords
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TGF-β-driven muscle degeneration and failed regeneration underlie disease onset in a DMD mouse model.

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recommendations! Published in 2020 at "JCI insight"

DOI: 10.1172/jci.insight.135703

Abstract: Duchenne muscular dystrophy (DMD) is a chronic muscle disease characterized by poor myogenesis and replacement of muscle by extracellular matrix. Despite the shared genetic basis, severity of these deficits varies among patients. One source of… read more here.

Keywords: muscle; disease; tgf; muscle degeneration ... See more keywords

Cardioprotective effect of nicorandil on isoproterenol induced cardiomyopathy in the Mdx mouse model

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recommendations! Published in 2021 at "BMC Cardiovascular Disorders"

DOI: 10.1186/s12872-021-02112-4

Abstract: Background Duchenne muscular dystrophy (DMD) associated cardiomyopathy is a major cause of morbidity and mortality. In an in vitro DMD cardiomyocyte model, nicorandil reversed stress-induced cell injury through multiple pathways implicated in DMD . We… read more here.

Keywords: dmd; isoproterenol; nicorandil isoproterenol; isoproterenol induced ... See more keywords