Omentum acts as a regulatory organ controlling skeletal muscle repair of mdx mice diaphragm
Sign Up to like & getrecommendations! Published in 2019 at "Cell and Tissue Research"
DOI: 10.1007/s00441-019-03012-y
Abstract: Duchenne muscular dystrophy is a lethal X-linked muscle wasting disease due to mutations of the dystrophin gene leading to distinct susceptibility to degeneration and fibrosis among skeletal muscles. This study aims at verifying whether intense… read more here.
Keywords: muscle; mdx mice; omentum acts; diaphragm ... See more keywords
Blockade of Bradykinin receptors worsens the dystrophic phenotype of mdx mice: differential effects for B1 and B2 receptors
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Communication and Signaling"
DOI: 10.1007/s12079-017-0439-x
Abstract: The Kallikrein Kinin System (KKS) is a vasoactive peptide system with known functions in the maintenance of tissue homeostasis, renal function and blood pressure. The main effector peptide of KKS is Bradykinin (BK). This ligand… read more here.
Keywords: receptors worsens; worsens dystrophic; mdx mice; mdx ... See more keywords
Social stress is lethal in the mdx model of Duchenne muscular dystrophy
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102700
Abstract: Background Duchenne muscular dystrophy (DMD) is caused by the loss of dystrophin. Severe and ultimately lethal, DMD progresses relatively slowly in that patients become wheelchair bound only around age twelve with a survival expectancy reaching… read more here.
Keywords: mdx mice; muscular dystrophy; stress; mdx ... See more keywords
Integrative effects of dystrophin loss on metabolic function of the mdx mouse
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31753-3
Abstract: Duchenne muscular dystrophy (DMD) is a disease marked by the development of skeletal muscle weakness and wasting. DMD results from mutations in the gene for the cytoskeletal protein dystrophin. The loss of dystrophin expression is… read more here.
Keywords: skeletal muscle; dystrophin loss; mdx mice; mice ... See more keywords
Supplementation with a selective amino acid formula ameliorates muscular dystrophy in mdx mice
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32613-w
Abstract: Duchenne muscular dystrophy (DMD) is one of the most common and severe forms of muscular dystrophy. Oxidative myofibre content, muscle vasculature architecture and exercise tolerance are impaired in DMD. Several studies have demonstrated that nutrient… read more here.
Keywords: muscle; mdx mice; muscular dystrophy; supplementation ... See more keywords
Functional muscle recovery following dystrophin and myostatin exon splice modulation in aged mdx mice.
Sign Up to like & getrecommendations! Published in 2019 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz125
Abstract: Duchenne muscular dystrophy (DMD) is a rare genetic disease affecting 1 in 3500-5000 newborn boys. It is due to mutations in the DMD gene with a consequent lack of dystrophin protein that leads to deterioration… read more here.
Keywords: dmd; dystrophin myostatin; muscle; mdx mice ... See more keywords
Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in mdx mice
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac641
Abstract: Abstract Current therapies for Duchenne muscular dystrophy (DMD) use phosphorodiamidate morpholino oligomers (PMO) to induce exon skipping in the dystrophin pre-mRNA, enabling the translation of a shortened but functional dystrophin protein. This strategy has been… read more here.
Keywords: mdx mice; dystrophin restoration; m23d; force ... See more keywords
Cilostazol attenuates oxidative stress and apoptosis in the quadriceps muscle of the dystrophic mouse experimental model
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Experimental Pathology"
DOI: 10.1111/iep.12461
Abstract: Duchenne muscular dystrophy (DMD) is the most severe and frequent form of muscular dystrophy. The mdx mouse is one of the most widely used experimental models to understand aspects of the biology of dystrophic skeletal… read more here.
Keywords: mdx mice; mdx; oxidative stress; muscle ... See more keywords
Microbes, metabolites and muscle: Metagenomic and metabolomic analyses in a mouse model of muscular dystrophy
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733048
Abstract: Skeletal muscle is the largest metabolic organ. The metabolic and endocrine nature of skeletal muscle allows for long-range signaling and influence over the enteric environment and the resident microbiota. Commensal microbial signaling can influence the… read more here.
Keywords: mdx mice; muscle; physiology; diaphragm ... See more keywords
Investigating the effects of thermoneutral housing on skeletal and cardiac muscle function in D2 mdx mice
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5792468
Abstract: Since its discovery, the mdx mouse has been the foundation for research on Duchenne muscular dystrophy (DMD) and its potential therapies. Although, nearly all studies using mdx mice as an experimental model have been conducted… read more here.
Keywords: housing; mdx mice; muscle; physiology ... See more keywords
TRIM72 Alleviates Muscle Inflammation in mdx Mice via Promoting Mitophagy-Mediated NLRP3 Inflammasome Inactivation
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/8408574
Abstract: Chronic muscle inflammation exacerbates the pathogenesis of Duchenne muscular dystrophy (DMD), which is characterized by progressive muscle degeneration and weakness. NLRP3 (nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3) inflammasome plays a key role… read more here.
Keywords: mdx mice; muscle; trim72; mitophagy ... See more keywords