Variable rescue of microtubule and physiological phenotypes in mdx muscle expressing different miniaturized dystrophins
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy113
Abstract: Delivery of miniaturized dystrophin genes via adeno-associated viral vectors is one leading approach in development to treat Duchenne muscular dystrophy. Here we directly compared the functionality of five mini- and micro-dystrophins via skeletal muscle-specific transgenic… read more here.
Keywords: microtubule; mini micro; mdx muscle; micro dystrophins ... See more keywords
Beneficial Role of Exercise in the Modulation of mdx Muscle Plastic Remodeling and Oxidative Stress
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DOI: 10.3390/antiox10040558
Abstract: Duchenne muscular dystrophy (DMD) is an X-linked recessive progressive lethal disorder caused by the lack of dystrophin, which determines myofibers mechanical instability, oxidative stress, inflammation, and susceptibility to contraction-induced injuries. Unfortunately, at present, there is… read more here.
Keywords: dmd; mdx muscle; muscle; exercise ... See more keywords