A Targeted Octahedral DNA Nanostructure Co-delivers siME3 and Doxorubicin to Enhance Collateral Lethality in ME2-Deficient Pancreatic Cancer.
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DOI: 10.1021/acs.nanolett.4c05123
Abstract: The genetic characteristics of pancreatic cancer (PC) are being revealed, but treatment strategies based on these profiles are developing slowly. About one-third of PC patients harbor SMAD4 mutations, with its homozygous deletions often accompanied by… read more here.
Keywords: me2 deficient; nanostructure; sime3 doxorubicin; dna nanostructure ... See more keywords