Restricted Mean Survival Time Analysis to Estimate SGLT2i–Associated Heterogeneous Treatment Effects on Primary and Secondary Prevention of Cardiorenal Outcomes in Patients With Type 2 Diabetes in Taiwan
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.46928
Abstract: Key Points Question Is restricted mean survival time (RMST) analysis feasible to translate comparative cardiovascular and kidney outcomes of sodium-glucose cotransporter-2 inhibitor (SGLT2i) vs dipeptidyl peptidase-4 inhibitor (DPP4i) therapy in routine clinical settings? Findings In… read more here.
Keywords: cardiorenal outcomes; restricted mean; analysis; mean survival ... See more keywords
A nonparametric simultaneous confidence band for biomarker effect on the restricted mean survival time
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9618
Abstract: Study of prognostic and predictive biomarkers plays an important role in the design and analysis of clinical trials. The Cox proportional hazards model is often used to study the biomarker main effect and the treatment‐biomarker… read more here.
Keywords: effect; biomarker; restricted mean; mean survival ... See more keywords
Designing superiority trials with window mean survival time as a primary endpoint.
Sign Up to like & getrecommendations! Published in 2023 at "Statistics in medicine"
DOI: 10.1002/sim.9738
Abstract: Window mean survival time (WMST), a simple extension of restricted mean survival time (RMST), allows for clinicians to evaluate the mean survival difference between treatment groups in specific windows of time during the follow-up period… read more here.
Keywords: time; primary endpoint; mean survival; window mean ... See more keywords
The Restricted Mean Survival Time as a Tool for Ranking Comparative Outcomes in a Narrative Review that Evaluates a Network of Randomized Trials: An Example Based on PCSK9 Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Cardiovascular Drugs"
DOI: 10.1007/s40256-020-00444-8
Abstract: Introduction On the basis of two randomized trials, evolocumab and alirocumab have been approved in patients with cardiovascular disease. The evidence on these two agents has been studied through different methods of analysis that span… read more here.
Keywords: survival time; network; narrative review; restricted mean ... See more keywords
Restricted Mean Survival Times to Improve Communication of Evidence from Cancer Randomized Trials and Observational Studies.
Sign Up to like & getrecommendations! Published in 2019 at "European urology"
DOI: 10.1016/j.eururo.2019.04.002
Abstract: Hazard ratios (HRs) are frequently misinterpreted. We describe an easily estimated complementary measure, the difference in restricted mean survival time (RMST), that requires fewer assumptions than the HR and is more readily interpretable. Reporting RMST-based… read more here.
Keywords: communication evidence; improve communication; restricted mean; survival times ... See more keywords
Estimation on conditional restricted mean survival time with counting process
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2019.1657129
Abstract: ABSTRACT In traditional survival analyses, hazard ratio (HR) is commonly used to evaluate treatment effects. However, HR may not be easy to interpret. Restricted mean survival time is a viable alternative to HR, particularly when… read more here.
Keywords: conditional restricted; survival time; counting process; time ... See more keywords
Deep neural networks for predicting restricted mean survival times
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa1082
Abstract: AVAILABILITY AND IMPLEMENTATION Restricted mean survival time (RMST) is a useful summary measurement of the time-to-event data, and it has attracted great attention for its straightforward clinical interpretation. In this article, I propose a deep… read more here.
Keywords: network; deep neural; network model; restricted mean ... See more keywords
Impact of the Radiation Factor on Mean Survival Time for Chernobyl Clean-up Workers with Solid Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Biology Bulletin"
DOI: 10.1134/s106235901911013x
Abstract: The aim of this study was to investigate the mean survival time for Chernobyl clean-up workers (liquidators) with diagnosed solid cancer. The cohort of liquidators contained 142 871 males who worked in the Chernobyl exclusion zone… read more here.
Keywords: mean survival; time chernobyl; time; survival time ... See more keywords
Predicting Difference in Mean Survival Time from Reported Hazard Ratios for Cancer Patients
Sign Up to like & getrecommendations! Published in 2019 at "Medical Decision Making"
DOI: 10.1177/0272989x19832879
Abstract: Background. Gain in mean survival time from new cancer treatments is a core component of cost-effectiveness analyses frequently used by payers for reimbursement decisions. Due to limited follow-up time, clinical trials rarely report this measure,… read more here.
Keywords: mean survival; differences mean; cancer; survival time ... See more keywords
Generalized fiducial inference for the restricted mean survival time.
Sign Up to like & getrecommendations! Published in 2023 at "Statistical methods in medical research"
DOI: 10.1177/09622802231163333
Abstract: The standard modeling approach for time-to-event outcomes subject to censoring is based on the hazard function, with hazard ratios capturing the effect of exposures on the risk of outcome. The restricted mean survival time, defined… read more here.
Keywords: time; generalized fiducial; restricted mean; mean survival ... See more keywords
Design of non-inferiority randomized trials using the difference in restricted mean survival times
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Trials"
DOI: 10.1177/1740774518792259
Abstract: Background/aims Non-inferiority trials with time-to-event outcomes are becoming increasingly common. Designing non-inferiority trials is challenging, in particular, they require very large sample sizes. We hypothesized that the difference in restricted mean survival time, an alternative… read more here.
Keywords: survival time; time; restricted mean; difference restricted ... See more keywords