Screening different host cell lines for the dynamic production of measles virus
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Progress"
DOI: 10.1002/btpr.2432
Abstract: Measles virus (MV) has a natural affinity for cancer cells and oncolytic MV preparations have therefore been investigated in several clinical trials as a potential treatment for cancer. The main bottleneck in the administration of… read more here.
Keywords: production; different host; host cell; host ... See more keywords
Removal of chromatin by salt-tolerant endonucleases for production of recombinant measles virus.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology progress"
DOI: 10.1002/btpr.3342
Abstract: Host cell DNA is a critical impurity in downstream processing of enveloped viruses. Especially, DNA in the form of chromatin is often neglected. Endonuclease treatment is an almost mandatory step in manufacturing of viral vaccines.… read more here.
Keywords: tolerant endonucleases; measles virus; salt tolerant; recombinant measles ... See more keywords
Molecular identification and characterization of measles virus genotypes circulating in Afghanistan, 2008–2018
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27707
Abstract: The measles virus (MV) remains a leading cause of morbidity and mortality in children under 5 years of age. Molecular identification of circulating wild‐type MV) strains is a vital component of the measles elimination program.… read more here.
Keywords: measles virus; identification; afghanistan 2008; molecular identification ... See more keywords
IgA targeting on the &agr;‐molecular recognition element (&agr;‐MoRE) of viral phosphoprotein inhibits measles virus replication by interrupting formation and function of P‐N complex intracellularly
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.11.014
Abstract: ABSTRACT Secretory IgA (SIgA) antibody is unique for its capability to transit through epithelial cells by transcytosis and thus has opportunities and probabilities to interact with all viral components during viral replication which may result… read more here.
Keywords: replication interrupting; inhibits measles; viral phosphoprotein; replication ... See more keywords
PIM 3 kinase, a proto-oncogene product, regulates phosphorylation of the measles virus nucleoprotein tail domain at Ser 479 and Ser 510.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.002
Abstract: The tail domain of the measles virus (MeV) N protein is typically phosphorylated at S479 and S510. However, the protein kinase responsible for this phosphorylation has not been identified. To identify the protein kinase responsible,… read more here.
Keywords: tail domain; kinase; measles virus; pim kinase ... See more keywords
Structural characteristics of measles virus entry.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in virology"
DOI: 10.1016/j.coviro.2020.04.002
Abstract: Measles virus, a member of the genus Morbillivirus, is highly contagious and still shows considerable mortality with over 100000 deaths annually, although efficient attenuated vaccines exist. Recent studies of measles virus haemagglutinin (MeV-H) and its… read more here.
Keywords: mev; structural characteristics; virus entry; mev protein ... See more keywords
Measles virus in cancer therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in virology"
DOI: 10.1016/j.coviro.2020.07.016
Abstract: Over the last years, the development of viruses to treat cancer patients has re-gained considerable attention. A genetically modified herpesvirus, Talimogene laherparepvec, has already been authorized for the treatment of melanoma patients. Also recombinant measles… read more here.
Keywords: virology; mev; virus cancer; cancer ... See more keywords
Impact of complement and difference of cell-based assay and ELISA in determination of neutralization capacity against mumps and measles virus.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2021.112957
Abstract: Neutralizing antibodies against mumps and measles virus are considered a correlate of protection against these diseases. Measurement of neutralizing antibodies is mostly performed using plaque reduction neutralization assay or 50% cell culture infective dose (CCID50)… read more here.
Keywords: mumps measles; capacity; assay elisa; neutralization capacity ... See more keywords
Enhancement of safety and immunogenicity of the Chinese Hu191 measles virus vaccine by alteration of the S-adenosylmethionine (SAM) binding site in the large polymerase protein
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2018.02.022
Abstract: Abstract The live-attenuated measles virus (MV) vaccine based on the Hu191 strain has played a significant role in controlling measles in China. However, it has considerable adverse effects that may cause public health burden. We… read more here.
Keywords: virus vaccine; binding site; hu191; sam binding ... See more keywords
A recombinant measles virus vaccine strongly reduces SHIV viremia and virus reservoir establishment in macaques
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DOI: 10.1038/s41541-021-00385-6
Abstract: Replicative vectors derived from live-attenuated measles virus (MV) carrying additional non-measles vaccine antigens have long demonstrated safety and immunogenicity in humans despite pre-existing immunity to measles. Here, we report the vaccination of cynomolgus macaques with… read more here.
Keywords: virus vaccine; viremia; recombinant measles; measles virus ... See more keywords
Diagnostic significance of lactate dehydrogenase in measles virus reinfection cases
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.13021
Abstract: Lactate dehydrogenase (LDH) levels in measles virus (MeV) reinfection cases for the diagnosis of measles have not been extensively studied. Thus, we evaluated the significance of serum LDH in the immune response of patients with… read more here.
Keywords: measles virus; group; reinfection; ldh ... See more keywords