Association Between Measurable Residual Disease in Patients With Intermediate-Risk Acute Myeloid Leukemia and First Remission, Treatment, and Outcomes
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DOI: 10.1001/jamanetworkopen.2021.15991
Abstract: Key Points Question Is there an association between dynamic measurable residual disease, treatment, and outcomes among adults with intermediate-risk acute myeloid leukemia? Findings In this registry-based cohort study that included 549 younger patients (aged 14-60… read more here.
Keywords: risk acute; myeloid leukemia; measurable residual; residual disease ... See more keywords
The early achievement of measurable residual disease negativity in the treatment of adults with Philadelphia‐negative B‐cell acute lymphoblastic leukemia is a strong predictor for survival
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25671
Abstract: The minimal or measurable residual disease (MRD) status following induction/consolidation chemotherapy is an important prognostic endpoint in adult patients with newly diagnosed acute lymphoblastic leukemia (ALL). However, the optimal time‐point (TP) of MRD assessment and… read more here.
Keywords: mrd; philadelphia negative; lymphoblastic leukemia; measurable residual ... See more keywords
Blinatumomab is associated with favorable outcomes in patients with B‐cell lineage acute lymphoblastic leukemia and positive measurable residual disease at a threshold of 10−4 and higher
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26634
Abstract: The presence of measurable residual disease (MRD) is the strongest predictor of relapse in acute lymphoblastic leukemia (ALL). We conducted a prospective, single‐arm, phase II study in adults with B‐cell ALL with MRD ≥1 × 10−4 after… read more here.
Keywords: residual disease; measurable residual; lymphoblastic leukemia; acute lymphoblastic ... See more keywords
Current treatment strategies for measurable residual disease in patients with acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Cancer"
DOI: 10.1002/cncr.32354
Abstract: Patients with acute myeloid leukemia (AML) who achieve a morphologic complete remission still can have measurable residual disease (MRD) detected by multiparametric flow cytometry, molecular methods, or cytogenetics. Such patients with MRD have a high… read more here.
Keywords: patients acute; myeloid leukemia; treatment; disease ... See more keywords
Development of a 27‐color panel for the detection of measurable residual disease in patients diagnosed with acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Cytometry Part A"
DOI: 10.1002/cyto.a.24667
Abstract: Acute myeloid leukemia (AML) measurable residual disease (MRD) evaluated by multiparametric flow cytometry (MFC) is a surrogate for progression‐free and overall survival in clinical trials and patient management. Due to the limited number of detection… read more here.
Keywords: myeloid leukemia; color; measurable residual; panel ... See more keywords
Flow cytometric evaluation of measurable residual disease in chronic lymphocytic leukemia: Where do we stand?
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DOI: 10.1002/hon.3037
Abstract: Measurable residual disease (MRD) has emerged as a relevant parameter of response to therapy in chronic lymphocytic leukemia (CLL). Although several methods have been developed, flow cytometry has emerged as the most useful and standardized… read more here.
Keywords: flow cytometric; residual disease; lymphocytic leukemia; measurable residual ... See more keywords
Minimal/Measurable Residual Disease Detection in Acute Leukemias by Multiparameter Flow Cytometry
Sign Up to like & getrecommendations! Published in 2018 at "Current Hematologic Malignancy Reports"
DOI: 10.1007/s11899-018-0479-1
Abstract: Purpose of ReviewMinimal or measurable residual disease (MRD) detected by multiparameter flow cytometry (MFC) is an independent prognostic indicator in acute leukemia. However, the predictive value of MFC MRD is affected by technical challenges, interpretive… read more here.
Keywords: mrd; measurable residual; residual disease; flow cytometry ... See more keywords
Measurable residual diseases in haematological malignancies: current applications and future direction
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DOI: 10.1016/s0145-2126(19)30291-7
Abstract: Minimal/ measurable residual diseases represents an independent prognostic indicator for several haematological malignancies helping to predict clinical outcome and enables for further assessment of the effectiveness of treatment. The methods of detection of MRD has… read more here.
Keywords: residual diseases; current applications; measurable residual; haematological malignancies ... See more keywords
Peripheral blood minimal/measurable residual disease assessed in flow cytometry in acute myeloblastic leukemia
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DOI: 10.1038/s41375-019-0393-0
Abstract: There are unsolved questions in the field of minimal/ measurable residual disease (MRD) detection by multiparameter flow cytometry (MFC) in acute myeloblastic leukemia (AML). One of them, the value of peripheral blood (PB) testing, is… read more here.
Keywords: mrd; measurable residual; minimal measurable; residual disease ... See more keywords
Investigation of measurable residual disease in acute myeloid leukemia by DNA methylation patterns
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DOI: 10.1038/s41375-021-01316-z
Abstract: Assessment of measurable residual disease (MRD) upon treatment of acute myeloid leukemia (AML) remains challenging. It is usually addressed by highly sensitive PCR- or sequencing-based screening of specific mutations, or by multiparametric flow cytometry. However,… read more here.
Keywords: dnam; myeloid leukemia; measurable residual; residual disease ... See more keywords
Molecular heterogeneity and measurable residual disease of rare NPM1 mutations in acute myeloid leukemia: a nationwide experience from the GBMHM study group
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DOI: 10.1038/s41375-022-01534-z
Abstract: TO THE EDITOR Nucleophosmin (NPM1)-mutated acute myeloid leukemia (AML) is a recognized entity related to distinctive biological, clinical, and prognostic features. Nearly all NPM1 variants are frame-shift mutations located in exon 11, inducing the insertion… read more here.
Keywords: study; acute myeloid; npm1 mutations; myeloid leukemia ... See more keywords