An adaptive design for the identification of the optimal dose using joint modeling of continuous repeated biomarker measurements and time-to-toxicity in phase I/II clinical trials in oncology
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DOI: 10.1177/0962280219837737
Abstract: We present a new adaptive dose-finding method, based on a joint modeling of longitudinal continuous biomarker activity measurements and time to first dose limiting toxicity, with a shared random effect. Estimation relies on likelihood that… read more here.
Keywords: measurements time; phase; joint modeling; biomarker ... See more keywords