Mec1 regulates PAS recruitment of Atg13 via direct binding with Atg13 during glucose starvation-induced autophagy.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2215126120
Abstract: Mec1 is a DNA damage sensor, which performs an essential role in the DNA damage response pathway and glucose starvation-induced autophagy. However, the functions of Mec1 in autophagy remain unclear. In response to glucose starvation,… read more here.
Keywords: glucose starvation; atg13; induced autophagy; starvation induced ... See more keywords
Stn1 supports Mec1 function in protecting stalled replication forks from degradation
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1011917
Abstract: Replication stress threatens genome integrity by exposing replication forks to nucleolytic degradation. In both yeast and humans, the checkpoint kinases Mec1 and Rad53 limit deleterious single-stranded DNA (ssDNA), yet the protective mechanisms remain incompletely defined.… read more here.
Keywords: replication; mec1; function; replication forks ... See more keywords
Distinct Functions in Regulation of Meiotic Crossovers for DNA Damage Response Clamp Loader Rad24(Rad17) and Mec1(ATR) Kinase.
Sign Up to like & getrecommendations! Published in 2019 at "Genetics"
DOI: 10.1534/genetics.119.302427
Abstract: The number and distribution of meiotic crossovers (COs) are highly regulated, reflecting the requirement for COs during the first round of meiotic chromosome segregation. CO control includes CO assurance and CO interference, which promote at… read more here.
Keywords: rad24; clamp loader; mec1; clamp ... See more keywords