Pramipexole inhibits formalin‐induce acute and long‐lasting mechanical hypersensitivity via NF‐kB pathway in rats
Sign Up to like & getrecommendations! Published in 2023 at "Drug Development Research"
DOI: 10.1002/ddr.22029
Abstract: Pain is one of the most frequent causes for patients to seek medical care. It interferes with daily functioning and affects the quality of life of the patient. There is a clear need to investigate… read more here.
Keywords: acute long; ppx; long lasting; mechanical allodynia ... See more keywords
Bone marrow‐derived mesenchymal stem cells alleviate paclitaxel‐induced mechanical allodynia in rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23207
Abstract: Anticancer drug paclitaxel (PTX) frequently causes painful peripheral neuropathy; however, no medication has been shown to be effective in the treatment of this debilitating side effect. We aimed to investigate the efficacy of two different… read more here.
Keywords: ptx; induced mechanical; bone marrow; allodynia ... See more keywords
Metabotropic glutamate receptor 5‐mediated inhibition of inward‐rectifying K+ channel 4.1 contributes to orofacial ectopic mechanical allodynia following inferior alveolar nerve transection in male mice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25181
Abstract: Inward‐rectifying K+ channel 4.1 (Kir4.1), which regulates the electrophysiological properties of neurons and glia by affecting K+ homeostasis, plays a critical role in neuropathic pain. Metabotropic glutamate receptor 5 (mGluR5) regulates the expression of Kir4.1… read more here.
Keywords: orofacial ectopic; allodynia; mechanical allodynia; ectopic mechanical ... See more keywords
Coexistence of Alterations of Gastrointestinal Function and Mechanical Allodynia in the Reserpine-Induced Animal Model of Fibromyalgia
Sign Up to like & getrecommendations! Published in 2019 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-019-05577-8
Abstract: BackgroundFibromyalgia (FM) is a disorder characterized by widespread chronic pain as core symptom and a broad range of comorbidities. Despite the prevalence of gastrointestinal (GI) comorbidities in patients with FM, GI functions have rarely been… read more here.
Keywords: coexistence alterations; rat; rim rat; mechanical allodynia ... See more keywords
Involvement of NF-κB and the CX3CR1 Signaling Network in Mechanical Allodynia Induced by Tetanic Sciatic Stimulation
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DOI: 10.1007/s12264-017-0149-7
Abstract: Tetanic stimulation of the sciatic nerve (TSS) triggers long-term potentiation in the dorsal horn of the spinal cord and long-lasting pain hypersensitivity. CX3CL1–CX3CR1 signaling is an important pathway in neuronal–microglial activation. Nuclear factor κB (NF-κB)… read more here.
Keywords: cx3cr1 signaling; cx3cr1; allodynia induced; involvement cx3cr1 ... See more keywords
Graded peripheral nerve injury creates mechanical allodynia proportional to the progression and severity of microglial activity within the spinal cord of male mice
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.11.018
Abstract: The reactivity of microglia within the spinal cord in response to nerve injury, has been associated with the development and maintenance of neuropathic pain. However, the temporal changes in microglial reactivity following nerve injury remains… read more here.
Keywords: nerve injury; injury; activity; mechanical allodynia ... See more keywords
Bixin attenuates mechanical allodynia, anxious and depressive-like behaviors associated with experimental diabetes counteracting oxidative stress and glycated hemoglobin
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DOI: 10.1016/j.brainres.2021.147557
Abstract: Neuropathic pain, depression, and anxiety are common comorbidities in diabetic patients, whose pathophysiology involves hyperglycemia-induced increased oxidative stress. Bixin (BIX), an apocarotenoid extracted from the seeds of Bixa orellana, has been used in traditional medicine… read more here.
Keywords: bixin; like behaviors; mechanical allodynia; bix ... See more keywords
Upregulation of NLRP3 via STAT3-dependent histone acetylation contributes to painful neuropathy induced by bortezomib
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DOI: 10.1016/j.expneurol.2018.01.011
Abstract: ABSTRACT Painful neuropathy, as a severe side effect of chemotherapeutic bortezomib, is the most common reason for treatment discontinuation. However, the mechanism by which administration of bortezomib leads to painful neuropathy remains unclear. In the… read more here.
Keywords: upregulation nlrp3; bortezomib; induced bortezomib; histone ... See more keywords
Patterns of nerve fiber impairments and neuronal activation in male diabetic rats with and without mechanical allodynia: a comparative study
Sign Up to like & getrecommendations! Published in 2021 at "Canadian Journal of Diabetes"
DOI: 10.1016/j.jcjd.2021.08.002
Abstract: Abstract Aim It is still clinically difficult to definitively distinguish between painful and nonpainful diabetic peripheral neuropathy (DPN). In this study, pain patterns were further categorized; diabetic rats were grouped according to the presence or… read more here.
Keywords: study; diabetic rats; neuronal activation; mechanical allodynia ... See more keywords
Intraplantar injection of sialidase reduces mechanical allodynia during inflammatory pain.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2016.10.008
Abstract: Sialic acids are highly charged glycoresidues that are attached to glycoproteins or glycosphingolipids, and they are associated with various biological functions. Gangliosides, sialic acid-containing glycosphingolipids, are abundant in neural tissues and play important roles in… read more here.
Keywords: injection sialidase; intraplantar injection; mechanical allodynia; sialidase ... See more keywords
The implication of transient receptor potential canonical 6 in BDNF-induced mechanical allodynia in rat model of diabetic neuropathic pain.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119308
Abstract: AIMS Brain-derived neurotrophic factor (BDNF) is vital in the pathogenesis of mechanical allodynia with a paucity of reports available regarding diabetic neuropathy pain (DNP). Herein we identified the involvement of BDNF in driving mechanical allodynia… read more here.
Keywords: dnp rats; allodynia; mechanical allodynia; bdnf induced ... See more keywords