Regulation of YAP/TAZ Activity by Mechanical Cues: An Experimental Overview.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8910-2_15
Abstract: YAP/TAZ activity is regulated by a complex network of signals that include the Hippo pathway, cell polarity complexes, and signaling receptors of the RTK, GPCR, and WNT pathways and by a seamlessly expanding number of… read more here.
Keywords: yap taz; taz activity; mechanical cues; regulation yap ... See more keywords
Mechanical Cues in Spinal Cord Injury.
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.04.052
Abstract: An estimated 500,000 people experience a spinal cord injury worldwide each year (1). At present, there is no treatment to repair spinal cord injury and restore lost function. Unlike mammals, animals such as fish, frogs,… read more here.
Keywords: cues spinal; mechanical cues; injury; cord injury ... See more keywords
Dynamic intracellular mechanical cues facilitate collective signaling responses
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DOI: 10.1016/j.isci.2021.102396
Abstract: Summary Collective behavior emerges in diverse life machineries, e.g., the immune responses to dynamic stimulations. The essential questions that arise here are that whether and how cells in vivo collectively respond to stimulation frequencies higher… read more here.
Keywords: dynamic intracellular; mechanical cues; intracellular mechanical; signaling responses ... See more keywords
Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09152-7
Abstract: Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for cholesterol, fatty acid, triacylglycerol and phospholipid synthesis. In… read more here.
Keywords: metabolism; regulatory element; mechanical cues; sterol regulatory ... See more keywords
Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP
Sign Up to like & getrecommendations! Published in 2019 at "Nature Cell Biology"
DOI: 10.1038/s41556-018-0270-5
Abstract: Extracellular matrix (ECM) mechanical cues have powerful effects on cell proliferation, differentiation and death. Here, starting from an unbiased metabolomics approach, we identify synthesis of neutral lipids as a general response to mechanical signals delivered… read more here.
Keywords: extracellular matrix; matrix; mechanical cues; lipin ... See more keywords
Nucleoli in epithelial cell collectives respond to tumorigenic, spatial, and mechanical cues
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-02-0070
Abstract: Cancer cells are known to have larger nucleoli, consistent with their higher transcriptional and translational demands. Meanwhile, on stiff extracellular matrix, normal epithelial cells can exhibit genomic and proteomic mechanoactivation toward tumorigenic transformations, such as… read more here.
Keywords: cell; epithelial cell; mechanical cues; cell collectives ... See more keywords
Fluctuations shape plants through proprioception
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DOI: 10.1126/science.abc6868
Abstract: Plant proprioception Plants are battered inside and out by mechanical forces such as gravity, wind, or a passerby plucking a flower. Moulia et al. review what is known about how plants sense and interpret mechanical… read more here.
Keywords: plant; shape; mechanical cues; internal external ... See more keywords
Mechanical Cues Regulate Histone Modifications and Cell Behavior
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DOI: 10.1155/2022/9179111
Abstract: Change of biophysical factors in tissue microenvironment is an important step in a chronic disease development process. A mechanical and biochemical factor from cell living microniche can regulate cell epigenetic decoration and, therefore, further induce… read more here.
Keywords: histone modifications; cues regulate; histone; mechanical cues ... See more keywords
ANTXR1 as a Potential Sensor of Extracellular Mechanical Cues.
Sign Up to like & getrecommendations! Published in 2023 at "Acta biomaterialia"
DOI: 10.2139/ssrn.4203114
Abstract: Cell adhesion molecules mediate cell-cell or cell-matrix interactions, some of which are mechanical sensors, such as integrins. Emerging evidence indicates that anthrax toxin receptor 1 (ANTXR1), a newly identified cell adhesion molecule, can also sense… read more here.
Keywords: cell; potential sensor; mechanical cues; extracellular mechanical ... See more keywords
Mechanical Aspects of Angiogenesis
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DOI: 10.3390/cancers13194987
Abstract: Simple Summary The formation of new blood vessels from already existing ones is a process of high clinical relevance, since it is of great importance for both physiological and pathological processes. In regard to tumors,… read more here.
Keywords: angiogenesis mechanical; angiogenesis; extracellular matrix; mechanical cues ... See more keywords