Perineural application of resiniferatoxin on uninjured L3 and L4 nerves completely alleviates thermal and mechanical hypersensitivity following L5 nerve injury in rats
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24884
Abstract: Fifth lumbar (L5) nerve injury in rats causes neuropathic pain manifested with thermal and mechanical hypersensitivity in the ipsilateral hind paw. This study aimed to determine whether the elimination of unmyelinated primary afferents of the… read more here.
Keywords: thermal mechanical; mechanical hypersensitivity; application; uninjured nerves ... See more keywords
Cannabigerol (CBG) attenuates mechanical hypersensitivity elicited by chemotherapy‐induced peripheral neuropathy
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Pain"
DOI: 10.1002/ejp.2016
Abstract: Cannabigerol (CBG) is a non‐psychoactive phytocannabinoid produced by the plant Cannabis sativa with affinity to various receptors involved in nociception. As a result, CBG is marketed as an over‐the‐counter treatment for many forms of pain.… read more here.
Keywords: cbg; cannabigerol cbg; cbg attenuates; mechanical hypersensitivity ... See more keywords
TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K+ current.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109884
Abstract: Pain, whether acute or persistent, is a serious medical problem worldwide. However, its management remains unsatisfactory, and new analgesic molecules are required. We show here that TAFA4 reverses inflammatory, postoperative, and spared nerve injury (SNI)-induced… read more here.
Keywords: induced mechanical; mechanical hypersensitivity; tafa4; type current ... See more keywords
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity
Sign Up to like & getrecommendations! Published in 2017 at "Nature Neuroscience"
DOI: 10.1038/nn.4454
Abstract: The skin is equipped with specialized mechanoreceptors that allow the perception of the slightest brush. Indeed, some mechanoreceptors can detect even nanometer-scale movements. Movement is transformed into electrical signals via the gating of mechanically activated… read more here.
Keywords: stoml3 oligomerization; small molecule; mechanical hypersensitivity;
Spinal high‐mobility group box‐1 induces long‐lasting mechanical hypersensitivity through the toll‐like receptor 4 and upregulation of interleukin‐1β in activated astrocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14812
Abstract: Intrathecal treatment with recombinant high‐mobility group box‐1 (rHMGB1) in naïve mice leads to a persistent and significantly decreased hind paw withdrawal threshold to mechanical stimuli, suggesting that spinal HMGB1 evokes abnormal pain processing. By contrast,… read more here.
Keywords: hmgb1; mechanical hypersensitivity; rhmgb1; hypersensitivity ... See more keywords
Involvement of TRPV4 ionotropic channel in tongue mechanical hypersensitivity in dry-tongue rats.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of oral science"
DOI: 10.2334/josnusd.18-0468
Abstract: Although xerostomia can cause persistent oral pain, the mechanisms underlying such pain are not well understood. To evaluate whether a phosphorylated p38 (pp38)-TRPV4 mechanism in trigeminal ganglion (TG) neurons has a role in mechanical hyperalgesia… read more here.
Keywords: mechanical hypersensitivity; tongue rats; dry tongue; hypersensitivity dry ... See more keywords
Combinations of Cannabidiol and Δ9-Tetrahydrocannabinol in Reducing Chemotherapeutic Induced Neuropathic Pain
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10102548
Abstract: Neuropathic pain is a condition that impacts a substantial portion of the population and is expected to affect a larger percentage in the future. This type of pain is poorly managed by current therapies, including… read more here.
Keywords: combinations cannabidiol; mechanical hypersensitivity; high thc; neuropathic pain ... See more keywords