Mechanical Loading of the Femoral Neck in Human Locomotion
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3529
Abstract: Advancing age and reduced loading are associated with a reduction in bone formation. Conversely, loading increases periosteal apposition and may reduce remodeling imbalance and slow age‐related bone loss, an important outcome for the proximal femur,… read more here.
Keywords: stair ambulation; femoral neck; neck; mechanical loading ... See more keywords
Protein Kinase G2 Is Essential for Skeletal Homeostasis and Adaptation to Mechanical Loading in Male but Not Female Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4746
Abstract: We previously showed that the NO/cGMP/protein kinase G (PKG) signaling pathway positively regulates osteoblast proliferation, differentiation, and survival in vitro, and that cGMP‐elevating agents have bone‐anabolic effects in mice. Here, we generated mice with an… read more here.
Keywords: protein kinase; female mice; mechanical loading; bone ... See more keywords
Sprouty 2, an Early Response Gene Regulator of FosB and Mesenchymal Stem Cell Proliferation During Mechanical Loading and Osteogenic Differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26035
Abstract: Sprouty 2 (Spry2), an inhibitor of MAP kinase signaling was previously shown by our group to be induced during mechanical loading of mesenchymal stem cells (MSCs). Here, we studied the implication of Spry2 activation during… read more here.
Keywords: mechanical loading; osteogenic differentiation; early response; loading ... See more keywords
The Diminishing Returns of Mechanical Loading and Potential Mechanisms that Desensitize Osteocytes
Sign Up to like & getrecommendations! Published in 2021 at "Current Osteoporosis Reports"
DOI: 10.1007/s11914-021-00693-9
Abstract: Adaptation to mechanical loading is critical to maintaining bone mass and offers therapeutic potential to preventing age-related bone loss and osteoporosis. However, increasing the duration of loading is met with “diminishing returns” as the anabolic… read more here.
Keywords: mechanisms desensitize; response; mechanical loading; potential mechanisms ... See more keywords
Magnetic Characterization of Ferromagnetic Shape Memory Components Under Defined Mechanical Loading
Sign Up to like & getrecommendations! Published in 2020 at "Shape Memory and Superelasticity"
DOI: 10.1007/s40830-020-00266-2
Abstract: The present paper introduces a novel test procedure for the quasistatic magnetic characterization of FSMA (ferromagnetic shape memory alloy) components under mechanical loading for the use in actuator-level modeling. Its development was necessary due to… read more here.
Keywords: magnetic characterization; mechanical loading; ferromagnetic shape; shape memory ... See more keywords
Influence of Vitamin D Status and Mechanical Loading on the Morphometric and Mechanical Properties of the Mouse Tibia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical and Biological Engineering"
DOI: 10.1007/s40846-018-0433-7
Abstract: It is well known that vitamin D and mechanical loading play important roles in bone growth and development. However, the combined effect of the maternal vitamin D status and mechanical loading on the bone quality… read more here.
Keywords: mechanical loading; vitamin status; bone; status mechanical ... See more keywords
Bone remodelling in the mouse tibia is spatio-temporally modulated by oestrogen deficiency and external mechanical loading: a combined in vivo/in silico study.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2020.09.011
Abstract: Osteoporosis disrupts the healthy remodelling process in bone and affects its mechanical properties. Mechanical loading has been shown to be effective in stimulating bone formation to mitigate initial bone loss. However, no study has investigated… read more here.
Keywords: bone; mechanical loading; mouse tibia;
Changes in mechanical loading affect arthritis-induced bone loss in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.115149
Abstract: Arthritis induces bone loss by inflammation-mediated disturbance of bone homeostasis. On the other hand, pain and impaired locomotion are highly prevalent in arthritis and result in reduced general physical activity and less pronounced mechanical loading.… read more here.
Keywords: mechanical loading; arthritis; bone loss;
Bone mass and adaptation to mechanical loading are sexually dimorphic in adult osteoblast-specific ERα knockout mice.
Sign Up to like & getrecommendations! Published in 2022 at "Bone"
DOI: 10.1016/j.bone.2022.116349
Abstract: Estrogen receptor-alpha (ERα) regulates bone mass and is implicated in bone tissue's response to mechanical loading. The effects of ERα deletion in mice depend on sex, anatomical location, and the cellular stage at which ERα… read more here.
Keywords: bone mass; mice; adult; adaptation ... See more keywords
Influence of debonding on nonlinear deflection responses of curved composite panel structure under hygro-thermo-mechanical loading–macro-mechanical FE approach
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Non-linear Mechanics"
DOI: 10.1016/j.ijnonlinmec.2020.103636
Abstract: Abstract The excess geometrical deformation due to the in-plane hygrothermal and transverse mechanical loading are computationally (through a customized MATLAB code) obtained for the weakly bonded structure using the different kinematic theories in combination with… read more here.
Keywords: macro mechanical; nonlinear deflection; mechanical loading; hygro thermo ... See more keywords
Effects of a passive back exoskeleton on the mechanical loading of the low-back during symmetric lifting.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biomechanics"
DOI: 10.1016/j.jbiomech.2019.109486
Abstract: Low-back pain is the number one cause of disability in the world, with mechanical loading as one of the major risk factors. Exoskeletons have been introduced in the workplace to reduce low back loading. During… read more here.
Keywords: symmetric lifting; ankle height; mechanical loading; low back ... See more keywords