Chondrocyte death after mechanically overloading degenerated human intervertebral disk explants is associated with a structurally impaired pericellular matrix
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2735
Abstract: A type VI collagen‐rich pericellular matrix (PCM) encloses both intervertebral disk (IVD) and articular cartilage chondrocytes. In the latter, the PCM protects the chondrocytes from mechanical overload, whereas tissue degeneration is associated with PCM destruction.… read more here.
Keywords: mechanical overload; overload; death; disk ... See more keywords
Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload
Sign Up to like & getrecommendations! Published in 2018 at "Nature biomedical engineering"
DOI: 10.1038/s41551-018-0280-4
Abstract: The integration of in vitro cardiac tissue models, human induced pluripotent stem cells (hiPSCs) and genome-editing tools allows for the enhanced interrogation of physiological phenotypes and recapitulation of disease pathologies. Here, using a cardiac tissue… read more here.
Keywords: mechanical overload; mybpc3 deficiency; contractile deficits; tissue ... See more keywords
Mechano growth factor attenuates mechanical overload-induced nucleus pulposus cell apoptosis through inhibiting the p38 MAPK pathway
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20182462
Abstract: Mechanical overload is a risk factor of disc degeneration. It can induce disc degeneration through mediating cell apoptosis. Mechano growth factor (MGF) has been reported to inhibit mechanical overload-induced apoptosis of chondrocytes. The present study… read more here.
Keywords: cell apoptosis; overload; overload induced; mechanical overload ... See more keywords
Mechanical overload induces TMJ disc degeneration via TRPV4 activation.
Sign Up to like & getrecommendations! Published in 2023 at "Oral diseases"
DOI: 10.1111/odi.14595
Abstract: OBJECTIVE The temporomandibular joint (TMJ) disc cushions intraarticular stress during mandibular movements. While mechanical overloading is related to cartilage degeneration, the pathogenesis of TMJ disc degeneration is unclear. Here, we determined the regulatory role of… read more here.
Keywords: mechanical overload; disc degeneration; tmj disc; trpv4 ... See more keywords
The influence of nutrients on mechanical overload-induced changes to skeletal muscle mRNA content.
Sign Up to like & getrecommendations! Published in 2022 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00075.2022
Abstract: Mechanical overload and nutrients influence skeletal muscle phenotype, with the combination sometimes having a synergistic effect. Muscle phenotypes influenced by these stimuli are mediated in part by changes to the muscle mRNA signature. However, the… read more here.
Keywords: mechanical overload; transcription; influence; muscle ... See more keywords
Decreased SIRT1 Activity Is Involved in the Acute Injury Response of Chondrocytes to Ex Vivo Injurious Mechanical Overload
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076521
Abstract: A better understanding of molecular events following cartilage injury is required to develop treatments that prevent or delay the onset of trauma-induced osteoarthritis. In this study, alterations to SIRT1 activity in bovine articular cartilage explants… read more here.
Keywords: sirt1 activity; mechanical overload; injury response; activity ... See more keywords