Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-221513
Abstract: Objectives To investigate the role of mechanical stress in cartilage ageing and identify the mechanistic association during osteoarthritis (OA) progression. Methods F-box and WD repeat domain containing 7 (FBXW7) ubiquitin ligase expression and chondrocyte senescence… read more here.
Keywords: cartilage; osteoarthritis; fbxw7; mechanical overloading ... See more keywords
Response to: Correspondence on ‘Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7’ by Loeser et al
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2022-222710
Abstract: In January 2022, we reported an important role for FBXW7 in the association between mechanical overloading, chondrocyte senescence and cartilage ageing in the pathology of osteoarthritis (OA). Our data support the idea that JNK signalling… read more here.
Keywords: mechanical overloading; chondrocyte senescence; jnk; correspondence ... See more keywords
Absence of Desmin Results in Impaired Adaptive Response to Mechanical Overloading of Skeletal Muscle
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DOI: 10.3389/fcell.2021.662133
Abstract: Background: Desmin is a muscle-specific protein belonging to the intermediate filament family. Desmin mutations are linked to skeletal muscle defects, including inherited myopathies with severe clinical manifestations. The aim of this study was to examine… read more here.
Keywords: skeletal muscle; mechanical overloading; muscle; adaptive response ... See more keywords
Urolithin A Protects Chondrocytes From Mechanical Overloading-Induced Injuries
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DOI: 10.3389/fphar.2021.703847
Abstract: Physiological mechanical stimulation has been shown to promote chondrogenesis, but excessive mechanical loading results in cartilage degradation. Currently, the underlying mechanotransduction pathways in the context of physiological and injurious loading are not fully understood. In… read more here.
Keywords: mechanical overloading; chondrocytes mechanical; overloading induced; protects chondrocytes ... See more keywords