A Systematic Study of Size Correlation and Young's Modulus Sensitivity for Cellular Mechanical Phenotyping by Microfluidic Approaches
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200628
Abstract: Cellular mechanical properties are a class of intrinsic biophysical markers for cell state and health. Microfluidic mechanical phenotyping methods have emerged as promising tools to overcome the challenges of low throughput and high demand for… read more here.
Keywords: size; cellular mechanical; mechanical phenotyping; correlation young ... See more keywords
Probing Multi-dimensional Mechanical Phenotyping of Intracellular Structures by Viscoelastic Spectroscopy.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b19597
Abstract: Mechanical phenotyping of complex cellular structures gives insight into the process and function of mechanotransduction in biological systems. Several methods have been developed to characterize intracellular elastic moduli, while direct viscoelastic characterization of intracellular structures… read more here.
Keywords: intracellular structures; viscoelastic spectroscopy; multi dimensional; spectroscopy ... See more keywords
Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01147-6
Abstract: To divide, most animal cells drastically change shape and round up against extracellular confinement. Mitotic cells facilitate this process by generating intracellular pressure, which the contractile actomyosin cortex directs into shape. Here, we introduce a… read more here.
Keywords: genes involved; genome scale; mechanical phenotyping; mitotic rounding ... See more keywords
Microfluidic-Based Mechanical Phenotyping of Androgen-Sensitive and Non-sensitive Prostate Cancer Cells Lines
Sign Up to like & getrecommendations! Published in 2019 at "Micromachines"
DOI: 10.3390/mi10090602
Abstract: Cell mechanical properties have been identified to characterize cells pathologic states. Here, we report our work on high-throughput mechanical phenotyping of androgen-sensitive and non-sensitive human prostate cancer cell lines based on a morphological rheological microfluidic… read more here.
Keywords: androgen; prostate cancer; mechanical phenotyping; androgen sensitive ... See more keywords