The Effect of Container Surface Passivation on Aggregation of Intravenous Immunoglobulin Induced by Mechanical Shock
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DOI: 10.1002/biot.202000096
Abstract: Aggregation of therapeutic proteins can result from a number of stress conditions encountered during their manufacture, transportation, and storage. This work shows the effects of two interrelated sources of protein aggregation: the chemistry and structure… read more here.
Keywords: container; surface; mechanical shock; surface passivation ... See more keywords
Modelling the Dynamic Behaviour of a Friction-Type Mechanical Shock Indicator
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DOI: 10.1007/s40799-018-0242-5
Abstract: This paper deals with the challenges associated with modelling a friction-type shock indicator used during product distribution. Cost-effective mechanical shock indicators are widely used to reveal if a package has been subjected to a shock… read more here.
Keywords: friction; mechanical shock; shock indicator; friction type ... See more keywords
Container surfaces control initiation of cavitation and resulting particle formation in protein formulations following application of mechanical shock.
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DOI: 10.1016/j.xphs.2019.11.015
Abstract: Mechanical shock may cause cavitation in vials containing liquid formulations of therapeutic proteins and generate protein aggregates and other particulates. To test whether common formulation components such as protein molecules, air bubbles or polysorbate 20… read more here.
Keywords: following application; formulations following; cavitation; mechanical shock ... See more keywords