YAP nuclear‐cytoplasmic translocation is regulated by mechanical signaling, protein modification, and metabolism
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DOI: 10.1002/cbin.11345
Abstract: Nuclear‐cytoplasmic transport is necessary for the biological function of nuclear proteins. The mechanism underlying this process is very complex and has been a subject of intense research. Yes‐associated protein (YAP), a Hippo signaling pathway effector,… read more here.
Keywords: protein; signaling protein; nuclear cytoplasmic; protein modification ... See more keywords
Simvastatin ameliorates altered mechanotransduction in uterine leiomyoma cells.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of obstetrics and gynecology"
DOI: 10.1016/j.ajog.2020.05.012
Abstract: BACKGROUND Uterine leiomyomas, the most common tumors of the female reproductive system, feature excessive deposition of disordered stiff extracellular matrix (ECM) and fundamentally altered mechanical signaling pathways . Specifically, these alterations impact the normal dynamic… read more here.
Keywords: leiomyoma cells; altered mechanotransduction; simvastatin; mechanical signaling ... See more keywords
Mechanical signaling in a pulmonary microvascular endothelial cell monolayer.
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DOI: 10.1016/j.bbrc.2019.08.169
Abstract: The mechanical microenvironment of an endothelial cell includes a stable protein scaffold on the basal side, flowing blood on the apical side and contractile cells on the lateral sides. Interaction with the protein scaffold and… read more here.
Keywords: monolayer; endothelial cell; microvascular endothelial; mechanical signaling ... See more keywords
Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function
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DOI: 10.1016/j.cub.2021.05.021
Abstract: The epidermis is a stratified epithelium in which structural and functional features are polarized across multiple cell layers. This type of polarity is essential for establishing the epidermal barrier, but how it is created and… read more here.
Keywords: desmosomes polarize; integrate chemical; polarize integrate; mechanical signaling ... See more keywords
A Novel Protective Role for Matrix Metalloproteinase-8 in the Pulmonary Vasculature.
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DOI: 10.1164/rccm.202108-1863oc
Abstract: Rationale: Mechanical signaling through cell-matrix interactions plays a major role in progressive vascular remodeling in pulmonary arterial hypertension (PAH). Matrix metalloproteinase-8 (MMP-8) is an interstitial collagenase involved in regulating inflammation and fibrosis of the lung… read more here.
Keywords: pulmonary vasculature; role; matrix; matrix metalloproteinase ... See more keywords