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   Articles with "mechanical stretch" as a keyword



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Mechanical stretch induces myelin protein loss in oligodendrocytes by activating Erk1/2 in a calcium-dependent manner.

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recommendations! Published in 2020 at "Glia"

DOI: 10.1002/glia.23827

Abstract: Myelin loss in the brain is a common occurrence in traumatic brain injury (TBI) that results from impact-induced acceleration forces to the head. Fast and abrupt head motions, either resulting from violent blows and/or jolts,… read more here.

Keywords: mechanical stretch; loss oligodendrocytes; protein loss; myelin protein ... See more keywords

Mechanical Stretch Promotes Macrophage Polarization and Inflammation via the RhoA-ROCK/NF-κB Pathway

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recommendations! Published in 2022 at "BioMed Research International"

DOI: 10.1155/2022/6871269

Abstract: Macrophages play an essential role in the pathogenesis of most inflammatory diseases. Recent studies have shown that mechanical load can influence macrophage function, leading to excessive and uncontrolled inflammation and even systemic damage, including cardiovascular… read more here.

Keywords: rock; rhoa rock; rhoa; rock pathway ... See more keywords

Mechanical Stretch Induces Senescence of Lung Epithelial Cells and Drives Fibroblast Activation by Paracrine Mechanisms.

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recommendations! Published in 2024 at "American journal of respiratory cell and molecular biology"

DOI: 10.1165/rcmb.2023-0449oc

Abstract: Severe lung injury requiring mechanical ventilation may lead to secondary fibrosis. Senescence, a cell response characterized by cell cycle arrest and a shift towards a proinflammatory/profibrotic phenotype, is one of the involved mechanisms. Here, we… read more here.

Keywords: senescence; mechanical stretch; lung epithelial; epithelial cells ... See more keywords

The Effects of Mechanical Stretch on Integrins and Filopodial-Associated Proteins in Normal and Glaucomatous Trabecular Meshwork Cells

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recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.886706

Abstract: The trabecular meshwork (TM) is the tissue responsible for regulating aqueous humor fluid egress from the anterior eye. If drainage is impaired, intraocular pressure (IOP) becomes elevated, which is a primary risk factor for primary… read more here.

Keywords: integrins filopodial; stretch; trabecular meshwork; mechanical stretch ... See more keywords

Metformin Promotes Mechanical Stretch-Induced Skin Regeneration by Improving the Proliferative Activity of Skin-Derived Stem Cells

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recommendations! Published in 2022 at "Frontiers in Medicine"

DOI: 10.3389/fmed.2022.813917

Abstract: Background Skin expansion by mechanical stretch is an essential and widely used treatment for tissue defects in plastic and reconstructive surgery; however, the regenerative capacity of mechanically stretched skin limits clinical treatment results. Here, we… read more here.

Keywords: stretched skin; mechanical stretch; mechanically stretched; stem ... See more keywords

Increased Susceptibility to Mechanical Stretch Drives the Persistence of Keloid Fibroblasts: An Investigation Using a Stretchable PDMS Platform

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recommendations! Published in 2024 at "Biomedicines"

DOI: 10.3390/biomedicines12102169

Abstract: Background: Keloids are a common fibrotic disease of the skin, with the pathological hallmark of excessive extracellular matrix synthesis due to abnormal fibroblast activity. Since keloids clinically arise in areas of high mechanical tension, the… read more here.

Keywords: mechanical stretch; increased susceptibility; susceptibility mechanical; platform ... See more keywords

Upregulation of iNOS Protects Cyclic Mechanical Stretch-Induced Cell Death in Rat Aorta Smooth Muscle Cells

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recommendations! Published in 2020 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms21228660

Abstract: Aortic dissection and aneurysm are associated with abnormal hemodynamic loads originating from hypertension. Our previous study demonstrated that cyclic mechanical stretch (CMS, mimicked hypertension) caused the death of rat aortic smooth muscle cells (RASMCs) in… read more here.

Keywords: death; death rat; mechanical stretch; cell death ... See more keywords

Mechanical Stretch Induced Skin Regeneration: Molecular and Cellular Mechanism in Skin Soft Tissue Expansion

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23179622

Abstract: Skin soft tissue expansion is one of the most basic and commonly used techniques in plastic surgery to obtain excess skin for a variety of medical uses. However, skin soft tissue expansion is faced with… read more here.

Keywords: tissue expansion; soft tissue; mechanical stretch; expansion ... See more keywords
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Unravelling the Impact of Cyclic Mechanical Stretch in Keratoconus—A Transcriptomic Profiling Study

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24087437

Abstract: Biomechanical and molecular stresses may contribute to the pathogenesis of keratoconus (KC). We aimed to profile the transcriptomic changes in healthy primary human corneal (HCF) and KC-derived cells (HKC) combined with TGFβ1 treatment and cyclic… read more here.

Keywords: cms; mechanical stretch; cyclic mechanical; tgf ... See more keywords

Naringenin attenuates fibroblast activation and inflammatory response in a mechanical stretch-induced hypertrophic scar mouse model

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recommendations! Published in 2017 at "Molecular Medicine Reports"

DOI: 10.3892/mmr.2017.7209

Abstract: The pathogenesis and therapy of hypertrophic scars (HS) have not yet been established. The aim of the present study was to investigate the potential effect of naringenin on HS and its underlying mechanisms. The mouse… read more here.

Keywords: mechanical stretch; naringenin; activation; mouse model ... See more keywords

Differentiation of human amniotic epithelial cells into osteoblasts is induced by mechanical stretch via the Wnt/β‑catenin signalling pathway

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recommendations! Published in 2018 at "Molecular Medicine Reports"

DOI: 10.3892/mmr.2018.9571

Abstract: Human amniotic epithelial cells (hAECs) have recently been recognized as a potential source of stem cells. The present study was designed to investigate the effects of mechanical stretch on the osteogenic differentiation of hAECs. As… read more here.

Keywords: medicine; stretch; mechanical stretch; haecs ... See more keywords