Measuring biological materials mechanics with atomic force microscopy ‐ Mechanical unfolding of biopolymers
Sign Up to like & getrecommendations! Published in 2022 at "Microscopy Research and Technique"
DOI: 10.1002/jemt.24136
Abstract: Biopolymers, such as polynucleotides, polypeptides and polysaccharides, are macromolecules that direct most of the functions in living beings. Studying the mechanical unfolding of biopolymers provides important information about their molecular elasticity and mechanical stability, as… read more here.
Keywords: microscopy; mechanics; force; unfolding biopolymers ... See more keywords
Mechanical Unfolding of Single Polyubiquitin Molecules Reveals Evidence of Dynamic Disorder
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.9b03701
Abstract: Mechanical unfolding of single polyubiquitin molecules subjected to a constant stretching force showed nonexponentiality in the measured probability density of unfolding (waiting time distribution) and the survival probability of the folded state during the course… read more here.
Keywords: mechanical unfolding; polyubiquitin molecules; dynamic disorder; disorder ... See more keywords
Mechanical unfolding of spectrin reveals a super-exponential dependence of unfolding rate on force
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46525-w
Abstract: We investigated the mechanical unfolding of single spectrin molecules over a broad range of loading rates and thus unfolding forces by combining magnetic tweezers with atomic force microscopy. We find that the mean unfolding force… read more here.
Keywords: mechanical unfolding; rate force; force; rate ... See more keywords
Mechanical unfolding of alpha- and beta-helical protein motifs.
Sign Up to like & getrecommendations! Published in 2019 at "Soft matter"
DOI: 10.1039/c8sm02046a
Abstract: Alpha-helices and beta-sheets are the two most common secondary structure motifs in proteins. Beta-helical structures merge features of the two motifs, containing two or three beta-sheet faces connected by loops or turns in a single… read more here.
Keywords: protein; mechanical unfolding; beta helices; beta ... See more keywords