Changes in the intra- and peri-cellular sclerostin distribution in lacuno-canalicular system induced by mechanical unloading
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-020-01135-9
Abstract: Mechanical stimuli regulate Sclerostin (Scl), a negative regulator of bone formation, expression in osteocytes. However, the detailed Scl distribution in osteocytes in response to mechanical unloading remains unclear. Twelve-week-old male rats were used. The sciatic… read more here.
Keywords: scl; mechanical unloading; distribution; expression ... See more keywords
Mechanical Unloading in Heart Failure.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.05.038
Abstract: Myocardial injury induces significant changes in ventricular structure and function at both the cellular and anatomic level, leading to ventricular remodeling and subsequent heart failure. Unloading left ventricular pressure has been studied in both the… read more here.
Keywords: heart; term; mechanical unloading; heart failure ... See more keywords
Evidence for synergy between sarcomeres and fibroblasts in an in vitro model of myocardial reverse remodeling.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2021.05.005
Abstract: We have created a novel in-vitro platform to study reverse remodeling of engineered heart tissue (EHT) after mechanical unloading. EHTs were created by seeding decellularized porcine myocardial sections with a mixture of primary neonatal rat… read more here.
Keywords: evidence synergy; reverse remodeling; synergy sarcomeres; mechanical unloading ... See more keywords
Effects of carvedilol and metoprolol on the myocardium during mechanical unloading in a rat heterotopic heart transplantation model
Sign Up to like & getrecommendations! Published in 2021 at "Cardiology in the Young"
DOI: 10.1017/s1047951121000196
Abstract: Abstract Background and objectives: Left ventricular assist devices enable recovery from severe heart failure and serve as a bridge to heart transplantation. However, chronic mechanical unloading can impair myocardial recovery. We aimed to assess myocyte… read more here.
Keywords: mechanical unloading; carvedilol metoprolol; heart; treatment ... See more keywords
Mechanical unloading in 3D-engineered muscle leads to muscle atrophy by suppressing protein synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00323.2021
Abstract: Three dimensional (3D)-engineered muscle is an useful approach to a more comprehensive understanding of molecular mechanisms underlying unloading-induced muscle atrophy. We investigated the effects of mechanical unloading on molecular muscle protein synthesis (MPS)- and muscle… read more here.
Keywords: muscle; muscle atrophy; mechanical unloading; engineered muscle ... See more keywords
The Role of Nonglycolytic Glucose Metabolism in Myocardial Recovery Upon Mechanical Unloading and Circulatory Support in Chronic Heart Failure
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circulationaha.119.044452
Abstract: Supplemental Digital Content is available in the text. Background: Significant improvements in myocardial structure and function have been reported in some patients with advanced heart failure (termed responders [R]) following left ventricular assist device (LVAD)–induced… read more here.
Keywords: mechanical unloading; post; heart; metabolism ... See more keywords
Effect of mechanical unloading on genome-wide DNA methylation profile of the failing human heart
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.161788
Abstract: Heart failure (HF) is characterized by global alterations in myocardial DNA methylation, yet little is known about the epigenetic regulation of the noncoding genome and potential reversibility of DNA methylation with left ventricular assist device… read more here.
Keywords: methylation; dna methylation; genome wide; mechanical unloading ... See more keywords
The heterotopic heart transplantation in mice as a small animal model to study mechanical unloading – Establishment of the procedure, perioperative management and postoperative scoring
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0214513
Abstract: Background Unloading of failing hearts by left ventricular assist devices induces an extensive cardiac remodeling which may lead to a reversal of the initial phenotype–or to its deterioration. The mechanisms underlying these processes are unclear.… read more here.
Keywords: heart; heterotopic heart; model study; mechanical unloading ... See more keywords
Impaired Diastolic Function Predicts Improved Ischemic Myocardial Flow by Mechanical Left Ventricular Unloading in a Swine Model of Ischemic Heart Failure
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.795322
Abstract: Background: Impact of mechanical left ventricular (LV) unloading on myocardial tissue perfusion and its regulating factors remain unclear. This study was conducted to elucidate the predictors of regional blood flow (RBF) improvement by mechanical LV… read more here.
Keywords: pressure; mechanical left; mechanical unloading; left ventricular ... See more keywords
Muscle Atrophy Induced by Mechanical Unloading: Mechanisms and Potential Countermeasures
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.00235
Abstract: Prolonged periods of skeletal muscle inactivity or mechanical unloading (bed rest, hindlimb unloading, immobilization, spaceflight and reduced step) can result in a significant loss of musculoskeletal mass, size and strength which ultimately lead to muscle… read more here.
Keywords: skeletal muscle; atrophy induced; mechanical unloading; muscle ... See more keywords
Novel Targets for a Combination of Mechanical Unloading with Pharmacotherapy in Advanced Heart Failure
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179886
Abstract: LVAD therapy is an effective rescue in acute and especially chronic cardiac failure. In several scenarios, it provides a platform for regeneration and sustained myocardial recovery. While unloading seems to be a key element, pharmacotherapy… read more here.
Keywords: pharmacotherapy; novel targets; failure; combination mechanical ... See more keywords