Bioinformatics‐based and molecular docking study on the mechanism of action of Galla chinensis in the treatment of diabetic foot ulcers
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2365
Abstract: Based on transcriptome sequencing and molecular biology, the active ingredient of Galla chinensis in the treatment of diabetic foot ulcers was identified, and its mechanism of action was analyzed. read more here.
Keywords: galla chinensis; diabetic foot; foot ulcers; chinensis treatment ... See more keywords
Insight into the Mechanism of Action and Peptide‐Membrane Interactions of Aib‐Rich Peptides: Multitechnique Experimental and Theoretical Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Chembiochem"
DOI: 10.1002/cbic.202000834
Abstract: The increase in resistant bacterial strains necessitates the identification of new antimicrobial molecules. Antimicrobial peptides (AMPs) are an attractive option because of evidence that bacteria cannot easily develop resistance to AMPs. The peptaibols, a class… read more here.
Keywords: mechanism; aib rich; rich peptides; mechanism action ... See more keywords
Synthesis, Biological Activity, and Mechanism of Action of 2‐Pyrazyl and Pyridylhydrazone Derivatives, New Classes of Antileishmanial Agents
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201800328
Abstract: In this work, we report the antileishmanial activity of 23 compounds based on 2‐pyrazyl and 2‐pyridylhydrazone derivatives. The compounds were tested against the promastigotes of Leishmania amazonensis and L. braziliensis, murine macrophages, and intracellular L. amazonensis amastigotes.… read more here.
Keywords: pyridylhydrazone derivatives; amazonensis; pyrazyl pyridylhydrazone; mechanism action ... See more keywords
Regulatory Safety Learning Driven by the Mechanism of Action: The Case of TNF‐α Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2127
Abstract: The summary of product characteristics (SmPCs) is an important information source that includes the adverse drug reactions (ADRs) associated with the drug. Drugs with the same mechanism of action are expected to have a similar… read more here.
Keywords: mechanism action; safety; tnf; tnf inhibitors ... See more keywords
Analytical quantification, intoxication case series, and pharmacological mechanism of action for N-ethylnorpentylone (N-ethylpentylone or ephylone).
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2502
Abstract: Synthetic cathinones continue to proliferate in clandestine drug markets worldwide. N-ethylnorpentylone (also known as N-ethylpentylone or ephylone) is a popular emergent cathinone, yet little information is available about its toxicology and pharmacology. Here we characterize… read more here.
Keywords: ethylnorpentylone; analytical quantification; ethylpentylone ephylone; pharmacological mechanism ... See more keywords
New drug approvals for 2022: Synthesis and clinical applications.
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal research reviews"
DOI: 10.1002/med.21976
Abstract: The U.S. Food and Drug Administration has approved a total of 37 new drugs in 2022, which are composed of 20 chemical entities and 17 biologics. In particular, 20 chemical entities, including 17 small molecule… read more here.
Keywords: new drug; synthesis; mechanism action; chemical ... See more keywords
Preliminary study of mechanism of action of SN38 derivatives. Physicochemical data, evidence of interaction and alkylation of DNA octamer d(GCGATCGC)2
Sign Up to like & getrecommendations! Published in 2017 at "Magnetic Resonance in Chemistry"
DOI: 10.1002/mrc.4508
Abstract: The synthesis of water‐soluble SN38 derivatives is presented, and their stability in solutions used during drug development studies has been investigated. A preliminary study of mechanism of action of 9‐aminomethyl SN38 is presented. Using NMR… read more here.
Keywords: sn38; preliminary study; study mechanism; mechanism action ... See more keywords
Low‐density lipoproteins protect sperm during cryopreservation in buffalo: Unraveling mechanism of action
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23434
Abstract: This study was carried out to reveal factors and the mechanism of action by which low‐density lipoproteins (LDLs) protect sperm better than egg yolk (EY) during cryopreservation. We extracted LDL from EY and compared the… read more here.
Keywords: extender; low density; cryopreservation; calcium ... See more keywords
Natural products in crop protection: thiosemicarbazone derivatives of 3-acetyl-N-benzylindoles as antifungal agents and their mechanism of action.
Sign Up to like & getrecommendations! Published in 2023 at "Pest management science"
DOI: 10.1002/ps.7457
Abstract: BACKGROUND Phytopathogenic fungi can cause a direct loss in economic value of agriculture. Especially Valsa mali Miyabe et Yamada, a devastating phytopathogenic disease especially threatening global apple production, is very difficult to control and manage.… read more here.
Keywords: thiosemicarbazone derivatives; thiosemicarbazone; acetyl benzylindoles; mechanism action ... See more keywords
Bioinformatics Approaches to Predict Drug Responses from Genomic Sequencing.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7493-1_14
Abstract: Fulfilling the promises of precision medicine will depend on our ability to create patient-specific treatment regimens. Therefore, being able to translate genomic sequencing into predicting how a patient will respond to a given drug is… read more here.
Keywords: genomic sequencing; sequencing data; bioinformatics approaches; approaches predict ... See more keywords
Molecular mechanism of action and pharmacokinetic properties of methotrexate
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05481-9
Abstract: Since its discovery in 1945, methotrexate has become a standard therapy for number of diseases, including oncological, inflammatory and pulmonary ones. Major physiological interactions of methotrexate include folate pathway, adenosine, prostaglandins, leukotrienes and cytokines. Methotrexate… read more here.
Keywords: pharmacokinetic properties; methotrexate; molecular mechanism; therapy ... See more keywords