A mechanism-based homogenization of a dislocation source model for bending
Sign Up to like & getrecommendations! Published in 2019 at "Acta Materialia"
DOI: 10.1016/j.actamat.2018.11.013
Abstract: Abstract The homogenization of dislocation dynamics including the mechanisms of dislocation nucleation is a great challenge in dislocation based continuum formulations. Due to the loss of the local and temporal resolution in a continuum model,… read more here.
Keywords: based homogenization; dislocation; model; mechanism based ... See more keywords
A reviewed vision of the oxygen reduction reaction mechanism on Pt-based catalysts
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Electrochemistry"
DOI: 10.1016/j.coelec.2018.03.008
Abstract: Summary In this work, a short revised analysis regarding the ORR mechanism at Pt-based surfaces has been performed and some common kinetic criteria have been reexamined in light of recent experimental results. In this sense,… read more here.
Keywords: reduction; mechanism; based catalysts; reaction ... See more keywords
Mechanism-based biomarker discovery.
Sign Up to like & getrecommendations! Published in 2017 at "Drug discovery today"
DOI: 10.1016/j.drudis.2017.04.013
Abstract: Biomarkers are cornerstones of healthcare spanning a wide spectrum of applications like disease diagnosis and stratification of patient populations. Despite significant efforts that have identified thousands of potential biomarkers, their translation into clinical practice remains… read more here.
Keywords: mechanism based; biomarker; biomarker discovery; based biomarker ... See more keywords
Lyophobicity and slagging resistance mechanism of h-BN based coating for coal-fired boilers
Sign Up to like & getrecommendations! Published in 2019 at "Fuel Processing Technology"
DOI: 10.1016/j.fuproc.2019.02.012
Abstract: Abstract Sodium reacts with sulfur oxide to form molten Na2SO4 during combustion of high-sodium coal (HSC). The resulting sticky inner layer captures ash to form slag, which inhibits heat transfer and flow of combustion gases.… read more here.
Keywords: resistance mechanism; fired boilers; lyophobicity slagging; slagging resistance ... See more keywords
This Is Not a Turn: Canadian Political Science and Social Mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "Canadian Journal of Political Science"
DOI: 10.1017/s0008423917000038
Abstract: Abstract Mechanism-based explanations are gaining in popularity in the social sciences. Canadian political science has somewhat embraced these debates. Recent work has explicitly identified with mechanismic explanation and, at the same time, there is a… read more here.
Keywords: science politique; politique canadienne; science; canadian political ... See more keywords
Methysticin Acts as a Mechanism-Based Inactivator of Cytochrome P450 2C9.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00098
Abstract: Methysticin is one of the naturally occurring bioactive constituents extracted from Piper methysticum Forst. In the present study, we intended to investigate the inhibitory effect of methysticin on cytochrome P450 (P450) enzymes. Methysticin exhibited time-,… read more here.
Keywords: mechanism based; cyp2c9; cytochrome p450; p450 ... See more keywords
Tofacitinib is a mechanism-based inactivator of cytochrome P450 3A4.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00141
Abstract: Tofacitinib (TFT) is an oral JAK inhibitor which has been approved for the treatment of moderately and severely active rheumatoid arthritis. TFT was found to show concentration-, time- and NADPH-dependent inhibition of CYP3A4, and irreversibility… read more here.
Keywords: tofacitinib; mechanism based; based inactivator; inactivation ... See more keywords
Cellulose Pyrolysis Mechanism Based on Functional Group Evolutions by Two-Dimensional Perturbation Correlation Infrared Spectroscopy
Sign Up to like & getrecommendations! Published in 2020 at "Energy & Fuels"
DOI: 10.1021/acs.energyfuels.0c00134
Abstract: To understanding the biomass pyrolysis process in depth, the pyrolysis mechanism of cellulose was investigated based on the combination of gas and liquid product releasing behavior with the structu... read more here.
Keywords: pyrolysis; cellulose pyrolysis; spectroscopy; mechanism based ... See more keywords
Multisource Attention-Mechanism-Based Encoder-Decoder Model for Predicting Drug-Drug Interaction Events
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c01112
Abstract: Many computational methods have been proposed to predict drug-drug interactions (DDIs), which can occur when combining drugs to treat various diseases, but most mainly utilize single-source features of drugs, which is inadequate for drug representation.… read more here.
Keywords: attention mechanism; mechanism based; drug drug; attention ... See more keywords
Mechanism-Based Rational Discovery and In Vitro Evaluation of Novel Microtubule Stabilizing Agents with Non-Taxol-Competitive Activity
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b01133
Abstract: Microtubules (MT) are cytoskeletal polymers of αβ-tubulin dimers that play a critical role in many cellular functions. Diverse antimitotic drugs bind to MT and disrupt their dynamics acting as MT stabilizing or destabilizing agents. The… read more here.
Keywords: rational discovery; based rational; discovery vitro; discovery ... See more keywords
Design and Characterization of the First Selective and Potent Mechanism-Based Inhibitor of Cytochrome P450 4Z1.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00101
Abstract: Mammary tissue-restricted cytochrome P450 4Z1 (CYP4Z1) has garnered interest for its potential role in breast cancer progression. CYP4Z1-dependent metabolism of arachidonic acid preferentially generates 14,15-epoxyeicosatrienoic acid (14,15-EET), a metabolite known to influence cellular proliferation, migration,… read more here.
Keywords: cyp4z1; p450 4z1; cytochrome p450; mechanism based ... See more keywords