Functional mechanism and clinical implications of MicroRNA‐423 in human cancers
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DOI: 10.1002/cam4.3557
Abstract: MicroRNAs play a vital role in the regulatory mechanisms of tumorigenesis. Current research indicates that microRNA‐423 (miR‐423) is abnormally expressed in various human tumors and participates in multiple signaling pathways of cancer progression. In most… read more here.
Keywords: functional mechanism; microrna 423; 423 human; mir 423 ... See more keywords
Abstract 3986: Regulation mechanism and clinical significance of KPNA2 promotes MDSCs infiltrating in epithelial ovarian cancer
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DOI: 10.1158/1538-7445.am2017-3986
Abstract: Myeloid-Derived Suppressor Cells (MDSCs) are a population of immune cells that negatively regulate immune responses, which could promote tumor invasion and metastasis. Recently research has revealed that tumor could actively reshape the immune-microenvironment for its… read more here.
Keywords: regulation mechanism; kpna2; ovarian cancer; cancer ... See more keywords
The TΑp63/BCL2 axis represents a novel mechanism of clinical aggressiveness in chronic lymphocytic leukemia
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DOI: 10.1182/bloodadvances.2021006348
Abstract: Key Points High expression of TAp63 is linked to adverse clinical outcomes in CLL. TAp63 contributes to the antiapoptotic phenotype of CLL cells, likely through modulating BCL2 protein expression. read more here.
Keywords: mechanism clinical; axis represents; represents novel; novel mechanism ... See more keywords
Glaucoma: Biological mechanism and its Clinical Translation.
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DOI: 10.2174/1566524022666220508182051
Abstract: Glaucoma is a common cause of visual loss and irreversible blindness, affecting visual and life quality. There are various mechanisms involved in retinal ganglion cell (RGC) apoptosis and functional and structural loss in the visual… read more here.
Keywords: mechanism clinical; glaucoma; clinical translation; glaucoma biological ... See more keywords
Cancer Cachexia: Its Mechanism and Clinical Significance
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DOI: 10.3390/ijms22168491
Abstract: The term “cachexia” is derived from the Greek words kakos (bad) and hexis (habit). Cachexia is a malnutrition associated with chronic diseases such as cancer, chronic heart failure, chronic renal failure, and autoimmune diseases, and… read more here.
Keywords: cachexia; cachexia mechanism; cancer cachexia; cancer ... See more keywords
[Paraquat poisoning mechanism and its clinical treatment progress].
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DOI: 10.3760/cma.j.issn.2095-4352.2017.11.018
Abstract: Paraquat (PQ) as a kind of sterile and herbicides, has effects of contact-kill and systemic action, which can be absorbed quickly by green plants and make them wither and die. Therefore, it is widely used… read more here.
Keywords: paraquat; poisoning mechanism; treatment; treatment progress ... See more keywords