Design and Mechanism of GABA Aminotransferase Inactivators. Treatments for Epilepsies and Addictions.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.8b00009
Abstract: When the brain concentration of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) diminishes below a threshold level, the excess neuronal excitation can lead to convulsions. This imbalance in neurotransmission can be corrected by inhibition of the… read more here.
Keywords: mechanism; gaba aminotransferase; design mechanism; mechanism gaba ... See more keywords