Structure and mechanism for iterative amide N-methylation in the biosynthesis of channel-forming peptide cytotoxins
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DOI: 10.1073/pnas.2116578119
Abstract: Significance The channel-forming proteusins are bacterial helical peptides that allow permeation of positively charged ions to influence membrane potential and cellular physiology. We biochemically characterize the effect of two critical posttranslational modifications on the secondary… read more here.
Keywords: structure mechanism; iterative amide; mechanism iterative; channel forming ... See more keywords