Diet-Induced Obesity and the Mechanism of Leptin Resistance.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-48382-5_16
Abstract: Leptin signaling blockade by chronic overstimulation of the leptin receptor or hypothalamic pro-inflammatory responses due to elevated levels of saturated fatty acid can induce leptin resistance by activating negative feedback pathways. Although, long form leptin… read more here.
Keywords: leptin resistance; leptin; mechanism leptin; leptin signaling ... See more keywords
Mechanism for leptin’s acute insulin-independent effect to reverse diabetic ketoacidosis
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DOI: 10.1172/jci88477
Abstract: The mechanism by which leptin reverses diabetic ketoacidosis (DKA) is unknown. We examined the acute insulin-independent effects of leptin replacement therapy in a streptozotocin-induced rat model of DKA. Leptin infusion reduced rates of lipolysis, hepatic… read more here.
Keywords: acute insulin; insulin independent; corticosterone; ketoacidosis ... See more keywords