Targeting KRAS(G12C): From Inhibitory Mechanism to Modulation of Antitumor Effects in Patients
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DOI: 10.1016/j.cell.2020.09.044
Abstract: KRAS mutations are among the most common genetic alterations in lung, colorectal, and pancreatic cancers. Direct inhibition of KRAS oncoproteins has been a long-standing pursuit in precision oncology, one established shortly after the discovery of… read more here.
Keywords: inhibitory mechanism; g12c inhibitory; targeting kras; mechanism modulation ... See more keywords