Proteomics-based screening of the target proteins associated with antidepressant-like effect and mechanism of nimesulide
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DOI: 10.1038/s41598-020-66420-z
Abstract: Nimesulide is an inhibitor of COX-2 with antioxidant and anti-inflammatory effects. However, few studies have explored the antidepressant mechanism of nimesulide. Here, we evaluated the therapeutic effects of nimesulide on CUMS rats. iTRAQ technology was… read more here.
Keywords: mechanism; effect; proteomics based; screening target ... See more keywords