The Genetic Mechanism of Resistance to Antibiotics in Bacillus pumilus 3-19 Strain
Sign Up to like & getrecommendations! Published in 2017 at "BioNanoScience"
DOI: 10.1007/s12668-016-0295-9
Abstract: Treatment of bacterial infections becomes increasingly complicated due to the emergence of bacterial resistance to antimicrobial agents. Until now, most studies on bacterial antibiotic resistance have focused mainly on clinically relevant isolates pathogenic microorganisms and… read more here.
Keywords: bacillus pumilus; pumilus strain; genetic mechanism; resistance ... See more keywords
Esterase mutation is a mechanism of resistance to antimalarial compounds
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14240
Abstract: Pepstatin is a potent peptidyl inhibitor of various malarial aspartic proteases, and also has parasiticidal activity. Activity of pepstatin against cultured Plasmodium falciparum is highly variable depending on the commercial source. Here we identify a… read more here.
Keywords: mutation mechanism; resistance; esterase mutation; pepstatin ... See more keywords
The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81343-z
Abstract: New antimalarial therapeutics are needed to ensure that malaria cases continue to be driven down, as both emerging parasite resistance to frontline chemotherapies and mosquito resistance to current insecticides threaten control programmes. Plasmodium, the apicomplexan… read more here.
Keywords: efficacy mechanism; mechanism; ddd01034957; resistance ... See more keywords
A Mechanism of Resistance to Antibody-Targeted Immune Attack
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-18-0266
Abstract: Antibody targeting of the EGFR on tumor cells is a form of immunotherapy that works by inducing NK-cell killing through antibody—NK-cell interactions. Resistance develops via the downregulation of the interaction molecules; thus, NK cells are… read more here.
Keywords: adcc; antibody; resistance; cell ... See more keywords
Discovery of a Novel Mechanism of Resistance to Thalidomide Derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-115110
Abstract: Pharmacologic agents that induce protein degradation represent an emerging and important class of therapeutic agents. Thalidomide and thalidomide derivatives (TDs) function by bringing target proteins and the E3 ubiquitin ligase substrate adaptor CRBN into proximity… read more here.
Keywords: degradation; resistance; crbn; activity ... See more keywords
Investigating macrophage function as a mechanism of resistance to daratumumab in relapsed refractory multiple myeloma patients.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e20547
Abstract: e20547Background: Daratumumab (Dara), an anti-CD38 antibody, has a variety of Fc-dependent immune effector mechanisms of action including macrophage-mediated antibody-dependent cellular phagocytosi... read more here.
Keywords: function mechanism; investigating macrophage; macrophage function; macrophage ... See more keywords
Dynamics Insights Into the Gain of Flexibility by Helix-12 in ESR1 as a Mechanism of Resistance to Drugs in Breast Cancer Cell Lines
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2019.00159
Abstract: Incidents of breast cancer (BC) are on the rise on a daily basis and have proven to be the most prevelant cause of death for women in both developed and developing countries. Among total BC… read more here.
Keywords: mechanism resistance; resistance; flexibility; breast cancer ... See more keywords