Structure and mechanism of the γ-secretase intramembrane protease complex.
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DOI: 10.1016/j.sbi.2022.102373
Abstract: γ-Secretase is a membrane protein complex that proteolyzes within the transmembrane domain of >100 substrates, including those derived from the amyloid precursor protein and the Notch family of cell surface receptors. The nine-transmembrane presenilin is… read more here.
Keywords: structure mechanism; protease complex; structure; secretase ... See more keywords