Articles with "mechanism suicide" as a keyword



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Unraveling the Abnormal Molecular Mechanism of Suicide Inhibition of Cytochrome P450 3A4

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Published in 2022 at "Journal of Chemical Information and Modeling"

DOI: 10.1021/acs.jcim.2c01035

Abstract: Suicide inhibition of the CYP3A4 enzyme by a drug inactivates the enzyme in the drug biotransformation process and often shows safety concerns about the drug. Despite extensive experimental studies, the abnormal molecular mechanism of a… read more here.

Keywords: suicide inhibition; abnormal molecular; molecular mechanism; mechanism suicide ... See more keywords