A general mechanism for transcription bubble nucleation in bacteria.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2220874120
Abstract: Bacterial transcription initiation requires σ factors for nucleation of the transcription bubble. The canonical housekeeping σ factor, σ70, nucleates DNA melting via recognition of conserved bases of the promoter -10 motif, which are unstacked and… read more here.
Keywords: mechanism transcription; transcription; transcription bubble; bubble nucleation ... See more keywords
Mechanism of transcription modulation by the transcription-repair coupling factor
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac449
Abstract: Elongation by RNA polymerase is dynamically modulated by accessory factors. The transcription-repair coupling factor (TRCF) recognizes distressed RNAPs and either rescues transcription or initiates transcription termination. Precisely how TRCFs choose to execute either outcome remains… read more here.
Keywords: transcription repair; coupling factor; transcription; modulation ... See more keywords
Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA
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DOI: 10.1093/nar/gky161
Abstract: Abstract Canonical bacterial transcription activators bind to non-transcribed promoter elements to increase transcription of their target genes. Here we report crystal structures of binary complexes comprising domains of Caulobacter crescentus GcrA, a noncanonical bacterial transcription… read more here.
Keywords: transcription; transcription activation; gcra; mechanism transcription ... See more keywords