Structural mechanism of TRPV3 channel inhibition by the plant-derived coumarin osthole.
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DOI: 10.15252/embr.202153233
Abstract: TRPV3, a representative of the vanilloid subfamily of TRP channels, is predominantly expressed in skin keratinocytes and has been implicated in cutaneous sensation and associated with numerous skin pathologies and cancers. TRPV3 is inhibited by… read more here.
Keywords: structural mechanism; mechanism trpv3; inhibition; channel inhibition ... See more keywords