Molecular Mechanisms of Cardiacvoltage-Gated Na+ Channel Regulation by Acidic pH
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DOI: 10.1016/j.bpj.2016.11.591
Abstract: Background: During ischemic heart disease, pH drops from 7.4 to 6.0 within 10 minutes of onset, severely affecting ion channel gating. The cardiac sodium channel (Nav1.5) is particularly susceptible to this abrupt pH change, and… read more here.
Keywords: mechanisms cardiacvoltage; channel regulation; cardiacvoltage gated; molecular mechanisms ... See more keywords