Synergistic interactions between NOD receptors and TLRs: Mechanisms and clinical implications
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2ru0718-290r
Abstract: Interactions between pattern recognition receptors (PRRs) shape innate immune responses to particular classes of pathogens. Here, we review interactions between TLRs and nucleotide‐binding oligomerization domain 1 and 2 (NOD1 and NOD2) receptors, two major groups… read more here.
Keywords: synergistic interactions; nod receptors; mechanisms clinical; interactions nod ... See more keywords
Vascular senescence and aging: mechanisms, clinical implications, and therapeutic prospects
Sign Up to like & getrecommendations! Published in 2025 at "Biogerontology"
DOI: 10.1007/s10522-025-10256-5
Abstract: The aging vasculature is characterized by endothelial dysfunction, arterial stiffness, and increased susceptibility to vascular pathologies. Central to these changes is the process of cellular senescence, where endothelial and vascular smooth muscle cells lose their… read more here.
Keywords: senescence; aging mechanisms; vascular senescence; secretory phenotype ... See more keywords
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
Sign Up to like & getrecommendations! Published in 2025 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-025-02145-7
Abstract: In the context of global ageing, the prevalence of neurodegenerative diseases and dementia, such as Alzheimer’s disease (AD), is increasing. However, the current symptomatic and disease-modifying therapies have achieved limited benefits for neurodegenerative diseases in… read more here.
Keywords: diseases mechanisms; antiageing strategy; mechanisms clinical; neurodegenerative diseases ... See more keywords
Basic mechanisms and clinical implications of ocular surface inflammation
Sign Up to like & getrecommendations! Published in 2024 at "Acta Ophthalmologica"
DOI: 10.1111/aos.16524
Abstract: Basic mechanisms and clinical implications of ocular surface inflammation.The pathopyhsiology of ocular surface inflammation is complex and involves a number of actors. Beside the immune system, a key role is emerging for the vasculature (both… read more here.
Keywords: mechanisms clinical; ocular surface; basic mechanisms; surface inflammation ... See more keywords
Proanthocyanidins against Oxidative Stress: From Molecular Mechanisms to Clinical Applications
Sign Up to like & getrecommendations! Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/8584136
Abstract: Proanthocyanidins (PCs) are naturally occurring polyphenolic compounds abundant in many vegetables, plant skins (rind/bark), seeds, flowers, fruits, and nuts. Numerous in vitro and in vivo studies have demonstrated myriad effects potentially beneficial to human health,… read more here.
Keywords: proanthocyanidins oxidative; stress molecular; mechanisms clinical; stress ... See more keywords
Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-19-1220
Abstract: Among more than 200 BAP1-mutant families affected by the "BAP1 cancer syndrome," nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies during their lifetime, mostly uveal and cutaneous melanoma, mesothelioma, and… read more here.
Keywords: bap1; cancer; mechanisms clinical; bap1 mutations ... See more keywords
Flavonoids in Autoimmune Diseases: Mechanisms, Clinical Evidence, and Future Directions.
Sign Up to like & getrecommendations! Published in 2025 at "Current pharmaceutical biotechnology"
DOI: 10.2174/0113892010399864251028081855
Abstract: Autoimmune diseases remain one of the top leading causes of morbidity and mortality globally. While several first-line therapies like corticosteroids, immunosuppressants, and DMARDs are proven effective, their prolonged use often leads to drug-induced complications. Researchers… read more here.
Keywords: diseases mechanisms; mechanisms clinical; clinical evidence; autoimmune diseases ... See more keywords
The Emerging Landscape of LINC01123 in Cancer: Roles, Mechanisms, and Clinical Significance.
Sign Up to like & getrecommendations! Published in 2025 at "Current drug targets"
DOI: 10.2174/0113894501398484250903074131
Abstract: INTRODUCTION Long intergenic non-coding RNA 01123 (LINC01123) is a lncRNA located on the human chromosome 2q13. It is upregulated in various cancers and has been identified as an oncogene. Its expression is associated with the… read more here.
Keywords: cancer; clinical significance; linc01123; mechanisms clinical ... See more keywords
Trabectedin in Cancers: Mechanisms and Clinical Applications.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical design"
DOI: 10.2174/1381612828666220526125806
Abstract: Trabectedin, a tetrahydroisoquinoline alkaloid, is the first marine antineoplastic agent approved with special anticancer mechanisms involving DNA binding, DNA repair pathways, transcription regulation and regulation of the tumor microenvironment. It has favorable clinical applications, especially… read more here.
Keywords: mechanisms clinical; trabectedin cancers; clinical applications; treatment ... See more keywords
The Regulatory Mechanisms and Clinical Significance of Lnc SNHG4 in Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical design"
DOI: 10.2174/1381612829666221121161950
Abstract: Background LncRNAs have been reported to be involved in a variety of biological functions, including gene expression, cell growth, and differentiation. They may also serve as oncogenes or tumor suppressor genes in diseases. lncRNAs that… read more here.
Keywords: mechanisms clinical; clinical significance; regulatory mechanisms; snhg4 ... See more keywords
MicroRNA-21 in urologic cancers: from molecular mechanisms to clinical implications
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2024.1437951
Abstract: The three most common kinds of urologic malignancies are prostate, bladder, and kidney cancer, which typically cause substantial morbidity and mortality. Early detection and effective treatment are essential due to their high fatality rates. As… read more here.
Keywords: urologic cancers; clinical implications; microrna urologic; molecular mechanisms ... See more keywords