Synergistic interactions between NOD receptors and TLRs: Mechanisms and clinical implications
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2ru0718-290r
Abstract: Interactions between pattern recognition receptors (PRRs) shape innate immune responses to particular classes of pathogens. Here, we review interactions between TLRs and nucleotide‐binding oligomerization domain 1 and 2 (NOD1 and NOD2) receptors, two major groups… read more here.
Keywords: synergistic interactions; nod receptors; mechanisms clinical; interactions nod ... See more keywords
Proanthocyanidins against Oxidative Stress: From Molecular Mechanisms to Clinical Applications
Sign Up to like & getrecommendations! Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/8584136
Abstract: Proanthocyanidins (PCs) are naturally occurring polyphenolic compounds abundant in many vegetables, plant skins (rind/bark), seeds, flowers, fruits, and nuts. Numerous in vitro and in vivo studies have demonstrated myriad effects potentially beneficial to human health,… read more here.
Keywords: proanthocyanidins oxidative; stress molecular; mechanisms clinical; stress ... See more keywords
Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-19-1220
Abstract: Among more than 200 BAP1-mutant families affected by the "BAP1 cancer syndrome," nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies during their lifetime, mostly uveal and cutaneous melanoma, mesothelioma, and… read more here.
Keywords: bap1; cancer; mechanisms clinical; bap1 mutations ... See more keywords
Trabectedin in Cancers: Mechanisms and Clinical Applications.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical design"
DOI: 10.2174/1381612828666220526125806
Abstract: Trabectedin, a tetrahydroisoquinoline alkaloid, is the first marine antineoplastic agent approved with special anticancer mechanisms involving DNA binding, DNA repair pathways, transcription regulation and regulation of the tumor microenvironment. It has favorable clinical applications, especially… read more here.
Keywords: mechanisms clinical; trabectedin cancers; clinical applications; treatment ... See more keywords
The Regulatory Mechanisms and Clinical Significance of Lnc SNHG4 in Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical design"
DOI: 10.2174/1381612829666221121161950
Abstract: Background LncRNAs have been reported to be involved in a variety of biological functions, including gene expression, cell growth, and differentiation. They may also serve as oncogenes or tumor suppressor genes in diseases. lncRNAs that… read more here.
Keywords: mechanisms clinical; clinical significance; regulatory mechanisms; snhg4 ... See more keywords
Revisiting Minocycline in Intracerebral Hemorrhage: Mechanisms and Clinical Translation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.844163
Abstract: Intracerebral hemorrhage (ICH) is an important subtype of stroke with an unsatisfactory prognosis of high mortality and disability. Although many pre-clinical studies and clinical trials have been performed in the past decades, effective therapy that… read more here.
Keywords: hemorrhage; mechanisms clinical; minocycline intracerebral; hemorrhage mechanisms ... See more keywords
Cardiac Calcifications: Phenotypes, Mechanisms, Clinical and Prognostic Implications
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11030414
Abstract: Simple Summary The clinical relevance of vascular calcifications has increased in recent years, given the aging of the population and increased exposure to risk factors. Tissue calcification is often a point of no return that… read more here.
Keywords: mechanisms clinical; calcification; calcifications phenotypes; cardiac calcifications ... See more keywords
The Serotonin Syndrome: From Molecular Mechanisms to Clinical Practice
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20092288
Abstract: The serotonin syndrome is a medication-induced condition resulting from serotonergic hyperactivity, usually involving antidepressant medications. As the number of patients experiencing medically-treated major depressive disorder increases, so does the population at risk for experiencing serotonin… read more here.
Keywords: clinical practice; serotonin syndrome; mechanisms clinical; syndrome molecular ... See more keywords
Eosinophilic Airway Diseases: From Pathophysiological Mechanisms to Clinical Practice
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087254
Abstract: Eosinophils play a key role in airway inflammation in many diseases, such as allergic and non-allergic asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. In these chronic disabling conditions, eosinophils contribute to… read more here.
Keywords: diseases pathophysiological; mechanisms clinical; pathophysiological mechanisms; airway diseases ... See more keywords
Antimicrobial Mechanisms and Clinical Application Prospects of Antimicrobial Peptides
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27092675
Abstract: Antimicrobial peptides are a type of small-molecule peptide that widely exist in nature and are components of the innate immunity of almost all living things. They play an important role in resisting foreign invading microorganisms.… read more here.
Keywords: application prospects; mechanisms clinical; clinical application; antimicrobial mechanisms ... See more keywords
Acute cardiorenal syndrome: Mechanisms and clinical implications
Sign Up to like & getrecommendations! Published in 2018 at "Cleveland Clinic Journal of Medicine"
DOI: 10.3949/ccjm.85a.17019
Abstract: Cardiac and renal dysfunction often coexist, and one begets the other. The association is referred to as cardio-renal syndrome. One subtype, acute cardiorenal syndrome, is often described as a clinical scenario in which acute worsening… read more here.
Keywords: acute cardiorenal; syndrome mechanisms; clinical implications; mechanisms clinical ... See more keywords